| 2396 |
Diminished differentiation of activated B lymphocytes
Short Name
Diminished differentiation of activated B lymphocytes
|
0 |
Cellular |
Dec 3, 2025 |
Dec 3, 2025 |
618: PPARgamma activation leads to a diminished vaccine response
|
| 2395 |
Diminished proliferation of activated B lymphocytes
Short Name
Diminished proliferation of activated B lymphocytes
|
0 |
Cellular |
Dec 3, 2025 |
Dec 3, 2025 |
618: PPARgamma activation leads to a diminished vaccine response
|
| 2394 |
Diminished survival of naive B lymphocytes
Short Name
Lower survival B lymphocytes
|
0 |
Cellular |
Dec 3, 2025 |
Dec 3, 2025 |
618: PPARgamma activation leads to a diminished vaccine response
|
| 2393 |
Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
Short Name
AR transcriptional activity in GT tissues, reduced
|
2 |
Cellular |
Dec 3, 2025 |
Dec 18, 2025 |
619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
|
| 2392 |
Depression
Short Name
Depression
|
0 |
Individual |
Nov 9, 2025 |
Nov 10, 2025 |
None
|
| 2391 |
Reduced fertility / fecundity
Short Name
Reduced fertility
|
0 |
Individual |
Nov 7, 2025 |
Nov 7, 2025 |
616: organic UV filter and its Photoproducts reproductive toxicity pathways
|
| 2390 |
KE5: Altered circulating reproductive hormones
Short Name
reproductive hormonal Imbalance
|
0 |
Organ |
Nov 7, 2025 |
Nov 7, 2025 |
616: organic UV filter and its Photoproducts reproductive toxicity pathways
|
| 2389 |
KE1: Altered steroidogenesis (gene/protein level)
Short Name
Altered steroidogenesis
|
0 |
Cellular |
Nov 7, 2025 |
Nov 7, 2025 |
616: organic UV filter and its Photoproducts reproductive toxicity pathways
|
| 2388 |
MIE-B: Photoactivation / photoproduct formation leading to ROS generation
Short Name
photoproducts generate ROS
|
0 |
Molecular |
Nov 7, 2025 |
Nov 7, 2025 |
616: organic UV filter and its Photoproducts reproductive toxicity pathways
|
| 2387 |
MIE-A: Direct ligand interaction with nuclear hormone receptors (ERα/ERβ, AR) or interference with steroidogenic enzymes (e.g., CYP19A1) → receptor activation/antagonism or enzyme inhibition.
Short Name
Nuclear receptor binding / steroidogenic enzyme interference
|
0 |
Molecular |
Nov 7, 2025 |
Nov 7, 2025 |
616: organic UV filter and its Photoproducts reproductive toxicity pathways
|
| 2386 |
Lipid-peroxidation overload
Short Name
Lipid-peroxidation overload
|
0 |
Cellular |
Nov 4, 2025 |
Nov 4, 2025 |
None
|
| 2385 |
Suppression of Keap1 cysteine oxidation
Short Name
Suppression of Keap1 cysteine oxidation
|
0 |
Molecular |
Nov 4, 2025 |
Nov 4, 2025 |
615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
|
| 2384 |
Decrease, Vascular integrity
Short Name
Decrease, Vascular integrity
|
1 |
Tissue |
Oct 29, 2025 |
Nov 7, 2025 |
2 AOPs
|
| 2383 |
Increase, Hemopericardium
Short Name
Increase, Hemopericardium
|
0 |
Organ |
Oct 29, 2025 |
Oct 29, 2025 |
3 AOPs
|
| 2382 |
Increase, nerve spasm
Short Name
Increase, nerve spasm
|
0 |
Individual |
Oct 20, 2025 |
Oct 20, 2025 |
611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
|
| 2381 |
Increase, transcription of the dopamine receptor (drd) gene.
Short Name
Increase, dopamine receptor gene
|
0 |
Molecular |
Oct 19, 2025 |
Oct 19, 2025 |
611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
|
| 2380 |
Increase, transcription of the dopamine transporter (SLC6A3) gene
Short Name
Increase, dopamine transporter gene
|
0 |
Molecular |
Oct 19, 2025 |
Oct 19, 2025 |
611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
|
| 2379 |
Disruption of the regulatory function of dopamine signaling components.
Short Name
Disruption, regulatory function of dopamine signaling components.
|
0 |
Molecular |
Oct 19, 2025 |
Oct 19, 2025 |
611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
|
| 2378 |
Impaired axonal insulation
Short Name
Impaired axonal insulation
|
0 |
Tissue |
Oct 8, 2025 |
Oct 8, 2025 |
610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
|
| 2377 |
Decrease, neural network maturation
Short Name
neural network formation
|
0 |
Tissue |
Oct 8, 2025 |
Oct 8, 2025 |
610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
|
| 2376 |
Inhibition, organic anion-transporting polypeptide 1C1 (OATP1C1)
Short Name
Inhibition, OATP1C1
|
0 |
Molecular |
Oct 8, 2025 |
Oct 8, 2025 |
610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
|
| 2375 |
Decrease, Mis-timed ecdysone receptor-responsive nuclear receptor cascade
Short Name
Decrease, Mis-timed EcR-responsive NR cascade
|
0 |
Cellular |
Sep 29, 2025 |
Sep 29, 2025 |
2 AOPs
|
| 2374 |
Increase, Ecdysone receptor antagonism
Short Name
Increase, EcR antagonism
|
0 |
Molecular |
Sep 29, 2025 |
Sep 29, 2025 |
2 AOPs
|
| 2373 |
Increase, Mis-timed ecdysone receptor-responsive nuclear receptor cascade
Short Name
Increase, Mis-timed EcR-responsive NR cascade
|
0 |
Cellular |
Sep 29, 2025 |
Sep 29, 2025 |
342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
|
| 2372 |
Squamous metaplasia, Increase
Short Name
Squamous metaplasia, Increase
|
1 |
Cellular |
Sep 12, 2025 |
Sep 16, 2025 |
None
|