AOP-Wiki

API

All Key Events

Showing 1226 to 1250 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1157	Activation, Hepatic nuclear receptor(s) Short Name Activation, Hepatic nuclear receptor(s)	1	Molecular	Nov 29, 2016	Nov 19, 2025	194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
1156	Inhibition, Dual oxidase Short Name Inhibition, Dual oxidase	1	Molecular	Nov 29, 2016	Nov 19, 2025	193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
1155	Inhibition, Pendrin Short Name Inhibition, Pendrin	1	Molecular	Nov 29, 2016	Nov 19, 2025	192: Pendrin inhibition leading to altered amphibian metamorphosis
1154	Increased, Triiodothyronine (T3) in tissues Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
1153	Inhibition, Deiodinase 3 Short Name Inhibition, Deiodinase 3	1	Molecular	Nov 29, 2016	Nov 19, 2025	191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
1152	Inhibition, Iodotyrosine deiodinase (IYD) Short Name	1	Molecular	Nov 29, 2016	Nov 18, 2025	188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
1151	Osteoporosis and vascular calcification, Bone deterioration Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1150	Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Impaired function of osteocalcin and MGP Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1149	Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone proteins (periostin, MGP and periostin like factor) not formed Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1148	Anticoagulant rodenticide interferes with gamma-carboxyglutamate formation, Inhibition of protein synthesis in bone Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1147	increased or inappropriate, mantel display Short Name	0	Individual	Nov 29, 2016	Dec 3, 2016	None
1146	premature, Spawning Short Name premature, Spawning	0	Individual	Nov 29, 2016	Jan 17, 2017	None
1145	Decreased, gametogenesis Short Name Decreased, gametogenesis	0		Nov 29, 2016	Nov 29, 2016	None
1144	premature, spawning 1 1 Short Name premature, spawning 1	0		Nov 29, 2016	Nov 29, 2016	None
1143	Depletion, energy reserves Short Name Depletion, energy reserves	0	Individual	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1142	Increased, valve movement Short Name Increased, valve movement	1	Tissue	Nov 29, 2016	Dec 3, 2016	4 AOPs 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1141	Decreased, Reproductive Success Short Name Decreased, Reproductive Success	0	Individual	Nov 29, 2016	Dec 3, 2016	4 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
1140	Delayed, Sexual maturity Short Name Delayed, Sexual maturity	0	Individual	Nov 29, 2016	Dec 3, 2016	None
1139	Increased, water retention in foot Short Name Increased, water retention in foot	0	Organ	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1138	Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP Short Name	2	Molecular	Nov 29, 2016	Sep 16, 2017	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1137	Under carboxylation of osteocalcin, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1136	Impaired recruitment , Population trajectory Short Name	1	Population	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1135	Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction Short Name	5	Tissue	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1134	Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone Short Name	3	Molecular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1133	Hemostasis, Depletion from blood of fully functional carboxylated clotting factors Short Name	2	Tissue	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage