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All Key Events

Showing 526 to 550 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

952	Hypertension Short Name Hypertension	1	Individual	Nov 29, 2016	Sep 27, 2017	2 AOPs 149: Peptide Oxidation Leading to Hypertension 516: Na+ /K+ -ATPase inhibition leading to hypertension
957	Binding, Transthyretin in serum Short Name Binding, Transthyretin in serum	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
958	Displacement, Serum thyroxine (T4) from transthyretin Short Name	1	Molecular	Nov 29, 2016	Dec 17, 2016	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
959	Increased, Free serum thyroxine (T4) Short Name Increased, Free serum thyroxine (T4)	1	Tissue	Nov 29, 2016	Sep 16, 2017	3 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
960	Increased, Uptake of thyroxine into tissue Short Name	1	Cellular	Nov 29, 2016	Dec 17, 2016	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
961	Increased, Clearance of thyroxine from serum Short Name	1	Tissue	Nov 29, 2016	Jan 26, 2021	7 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
962	Increase, Mucin production Short Name Increase, Mucin production	2	Cellular	Nov 29, 2016	Mar 9, 2023	148: EGFR Activation Leading to Decreased Lung Function
964	Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
968	Decreased, release of kisspeptin from anteroventral periventricular nucleus (AVPV) neurons Short Name	1	Cellular	Nov 29, 2016	Jan 28, 2026	2 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
969	Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
970	Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
971	Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation Short Name Reduced Ovulation of oocytes	1	Individual	Nov 29, 2016	May 19, 2020	2 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 616: organic UV filter and its Photoproducts reproductive toxicity pathways
972	Decreased fertility, Reduced number of oocytes ovulated Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
973	KE5 : Decrease, AKT/eNOS activity Short Name Decrease, AKT/eNOS activity	2	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
974	The binding of FK506 with FKBP12, Short Name The binding of FK506 with FKBP12,	0		Nov 29, 2016	Nov 29, 2016	None
975	The binding of FK506 with FKBP12, The binding of FK506 with FKBP12 Short Name	0		Nov 29, 2016	Nov 29, 2016	None
976	Formation, The binding of FK506 with FKBP12 Short Name	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
977	Binding, Binding of calcineurin with FK506-FKBP complexes Short Name	0		Nov 29, 2016	Nov 29, 2016	None
978	Activation, Suppression of NFAT activation and hindrance of nuclear localization Short Name	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
979	Interference, nuclear localization of NFAT Short Name	1	Molecular	Nov 29, 2016	Jul 2, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
980	Inhibition, Calcineurin Activity Short Name Inhibition, Calcineurin Activity	2	Molecular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
981	Reduction, NFAT/AP-1 complex formation Short Name Reduction, NFAT/AP-1 complex formation	2	Cellular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
982	Suppression, Suppression in mixed lymphocyte reaction (MLR) Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
983	Suppression, Suppression of T-cell dependent antibody response (TDAR) Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
984	Impairment, T-cell dependent antibody response Short Name	1	Individual	Nov 29, 2016	Feb 19, 2023	2 AOPs 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response