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All Key Events

Showing 1301 to 1325 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1785	Increase, Mitochondrial ATP synthase antagonism Short Name	0	Molecular	May 8, 2020	Dec 4, 2020	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
1786	Nipple retention (NR), increased Short Name nipple retention, increased	0	Individual	May 11, 2020	Jan 11, 2023	3 AOPs 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
1787	Downregulation, ACE2 Short Name Downregulation of ACE2	0	Cellular	May 15, 2020	Mar 31, 2021	3 AOPs 381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1788	Status epilepticus Short Name Status epilepticus	1	Individual	May 21, 2020	May 21, 2020	281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
1789	Reduction, 17beta-estradiol synthesis by the undifferentiated gonad Short Name	1	Cellular	Jun 15, 2020	Jul 13, 2022	346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
1790	Increased, Differentiation to Testis Short Name Increased, Differentiation to Testis	1	Tissue	Jun 15, 2020	Dec 28, 2022	2 AOPs 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 376: Androgen receptor agonism leading to male-biased sex ratio
1791	Increased, Male Biased Sex Ratio Short Name Increased, Male Biased Sex Ratio	1	Population	Jun 15, 2020	Jan 3, 2023	2 AOPs 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 376: Androgen receptor agonism leading to male-biased sex ratio
1792	Toll-like receptor 4 activation Short Name TLR4 activation	0	Molecular	Jul 9, 2020	Jul 9, 2020	347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1793	Activator protein 1 activation Short Name AP-1 activation	0	Cellular	Jul 9, 2020	Jul 9, 2020	347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1794	Pin-1 activation Short Name Pin-1 activation	0	Cellular	Jul 9, 2020	Jul 9, 2020	347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1795	Latent Transforming growth Factor beta expression Short Name TGFbeta expression	0	Cellular	Jul 9, 2020	Jul 9, 2020	347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1796	11β-hydroxylase inhibition Short Name 11β-hydroxylase inhibition	0	Molecular	Jul 13, 2020	Jul 13, 2020	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
1798	Decreased spermatogenesis Short Name Decreased spermatogenesis	0	Organ	Jul 13, 2020	Feb 9, 2021	3 AOPs 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 396: Deposition of ionizing energy leads to population decline via impaired meiosis 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
1799	Inhibition of 11β-HSD Short Name Inhibition of 11β-HSD	0	Molecular	Jul 13, 2020	Jul 13, 2020	348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
1800	Granulosa cell proliferation of gonadotropin-independent follicles, Reduced Short Name Reduced granulosa cell proliferation	1	Cellular	Oct 13, 2020	Apr 20, 2022	345: Androgen receptor (AR) antagonism leading to decreased fertility in females
1806	Inhibition, Chitinase Short Name Inhibition, Chitinase	0	Molecular	Oct 21, 2020	Sep 8, 2021	358: Chitinase inhibition leading to mortality
1807	Inhibition, Chitobiase Short Name Inhibition, Chitobiase	0	Molecular	Oct 21, 2020	Sep 8, 2021	359: Chitobiase inhibition leading to mortality
1808	Decrease, ATP synthase activity Short Name Decrease, ATP synthase activity	0	Molecular	Nov 2, 2020	Nov 2, 2020	None
1809	Increase, Tissue/organ damage Short Name Increase, Tissue/organ damage	0	Organ	Nov 2, 2020	Nov 2, 2020	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1810	Decrease, Plasma membrane ATPase activity Short Name Decrease, ATPase activity	0	Cellular	Nov 2, 2020	Nov 2, 2020	None
1811	Increase, Mitochondrial complex III dysfunction Short Name Increase, Complex III dysfunction	0	Molecular	Nov 2, 2020	Nov 2, 2020	None
1812	Increase, Cytochrome c release Short Name Increase, Cyt c release	0	Cellular	Nov 2, 2020	Nov 2, 2020	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1813	Increase, Mitochondrial complex I dysfunction Short Name Increase, Complex I dysfunction	0	Molecular	Nov 2, 2020	Nov 2, 2020	None
1814	benzoquinone imine and acylglucuronide metabolites Short Name Reactive Metabolite	0	Molecular	Nov 2, 2020	Nov 2, 2020	362: Immune mediated hepatitis
1815	Increase, Endoplasmic reticulum stress Short Name Increase, ER stress	0	Cellular	Nov 2, 2020	Feb 11, 2026	4 AOPs 362: Immune mediated hepatitis 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress