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All KERs

Showing 1276 to 1300 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2296	1849: Impaired gustatory nerve	1850: taste impairment	Mar 28, 2021	Mar 28, 2021	1 AOP 381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1815	1572: Impaired IL-1 signaling	1565: Suppressed AP-1	Dec 25, 2018	Dec 25, 2018	None
1816	1572: Impaired IL-1 signaling	1566: Suppressed NF-kB	Dec 25, 2018	Dec 25, 2018	None
1825	1572: Impaired IL-1 signaling	1573: Suppressed MyD88	Jan 6, 2019	Mar 14, 2019	None
1920	1572: Impaired IL-1 signaling	202: Inhibition, Nuclear factor kappa B (NF-kB)	May 23, 2019	Jun 25, 2019	None
2000	1700: Impaired IL-1R1 signaling	1702: Suppression of T cell activation	Nov 17, 2019	Nov 17, 2019	None
2002	1700: Impaired IL-1R1 signaling	202: Inhibition, Nuclear factor kappa B (NF-kB)	Nov 17, 2019	Sep 29, 2022	1 AOP 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
1938	1615: Impaired inguinoscrotal phase	1616: Malformation, cryptorchidism	Jun 3, 2019	Dec 3, 2024	2 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 528: Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
3179	2144: Impaired insulin signaling	2119: Increase, Insulin resistance	Apr 9, 2024	Apr 9, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
2515	1946: Altered mechanotransduction properties of pericytes	1947: Pericyte dysfunction	Oct 28, 2021	Oct 28, 2021	None
1990	1695: Impaired ovulation	1696: Decrease of egg production and cummulative fecundity	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
3470	1695: Impaired ovulation	2303: Plasma estradiol/progesterone ratio, increase	Jan 10, 2025	Jan 14, 2025	1 AOP 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
1976	1678: Impaired oxygenation of the blood	1679: Acute inhalation toxicity	Jul 3, 2019	Jul 3, 2019	None
3029	2179: Impaired Platelet Aggregation	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3425	2287: Impaired Sodium-Calcium Exchange	389: Increased, Intracellular Calcium overload	Nov 21, 2024	Nov 21, 2024	1 AOP 556: Decreased Na/K ATPase activity leading to heart failure
1821	1569: Impaired T cell activation	983: Suppression, Suppression of T-cell dependent antibody response (TDAR)	Dec 25, 2018	Dec 25, 2018	None
1822	1569: Impaired T cell activation	986: Impairment of TDAR	Dec 25, 2018	Jun 1, 2019	None
1922	1569: Impaired T cell activation	1644: Impaired Ab production	May 23, 2019	Jun 25, 2019	None
3618	2080: Impaired, blood testis barrier	520: Decreased sperm quantity or quality in the adult, Decreased fertility	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
572	577: impaired, Development	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	1 AOP 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure
574	568: impaired, Hive thermoregulation	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1153	568: impaired, Hive thermoregulation	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	1 AOP 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
701	697: impaired, ion channels	698: Altered, Action Potential	Nov 29, 2016	Dec 3, 2016	1 AOP 104: Altered ion channel activity leading impaired heart function
563	566: impaired, Larval development	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	4 AOPs 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
3460	566: impaired, Larval development	2302: Increase, Malformations	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.

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