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Showing 1401 to 1425 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2118	1784: Increase, Ovarian follicle breakdown (F3)	1782: Decrease, Oogenesis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
2107	1777: Increase, Ovarian follicle breakdown	1366: Decrease, Oogenesis	Apr 30, 2020	Apr 30, 2020	1 AOP 337: DNA methyltransferase inhibition leading to population decline (2)
2560	1777: Increase, Ovarian follicle breakdown	328: Decrease, Fecundity	Feb 4, 2022	Feb 4, 2022	None
1747	1526: Increase, Opening of voltage-dependent calcium channel	1523: Decrease, Cuticular chitin content	May 24, 2018	May 24, 2018	1 AOP 361: Sulfonylureareceptor binding leading to mortality
2113	1780: Increase, Oocyte apoptosis (F3)	1782: Decrease, Oogenesis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 340: DNA methyltransferase inhibition leading to transgenerational effects (1)
2104	1775: Increase, Oocyte apoptosis	1366: Decrease, Oogenesis	Apr 30, 2020	Apr 30, 2020	5 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 338: DNA methyltransferase inhibition leading to population decline (3) 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2386	1775: Increase, Oocyte apoptosis	406: decreased, Fertility	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2400	1775: Increase, Oocyte apoptosis	1696: Decrease of egg production and cummulative fecundity	May 18, 2021	May 18, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
1344	1264: Increase, E75b expression	1265: Decrease, Ftz-f1 expression	Feb 9, 2017	Feb 9, 2017	1 AOP 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
726	733: Increase, Necrosis (terminal bronchiolar cells)	734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
1874	1607: Increase, Necrosis	350: Increase, Mortality	Mar 19, 2019	Mar 19, 2019	None
2122	1607: Increase, Necrosis	1777: Increase, Ovarian follicle breakdown	May 8, 2020	May 8, 2020	None
2177	1607: Increase, Necrosis	1809: Increase, Tissue/organ damage	Nov 2, 2020	Nov 2, 2020	None
2465	1607: Increase, Necrosis	759: Increased, Kidney Failure	Aug 11, 2021	Aug 11, 2021	1 AOP 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
1443	1341: Increase, myosin light chain phosphorylation	1342: Increase, vascular smooth muscle contraction	Apr 14, 2017	Apr 14, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1356	1272: Increase, Myofibroblast expansion	1274: Production of α-smooth muscle actin	Feb 15, 2017	Feb 15, 2017	None
3813	2435: Myocardial and vascular structural remodeling	2437: Blood pressure elevation	Jul 9, 2026	Jul 9, 2026	None
3814	2435: Myocardial and vascular structural remodeling	2438: Cardiovascular aging	Jul 9, 2026	Jul 9, 2026	1 AOP 645: Binding and activation of AhR lead to cardiovascular aging
3826	2435: Myocardial and vascular structural remodeling	2445: Blood pressure	Jul 24, 2026	Jul 24, 2026	1 AOP 645: Binding and activation of AhR lead to cardiovascular aging
894	876: Increase, Mutations in Critical Genes	872: Increase, Site of Contact Nasal Tumors	Nov 29, 2016	Dec 1, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
202	185: Increase, Mutations	336: Increase, Heritable mutations in offspring	Nov 29, 2016	Nov 29, 2016	1 AOP 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
899	185: Increase, Mutations	885: Increase, Cancer	Nov 29, 2016	Dec 3, 2016	2 AOPs 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1
1896	185: Increase, Mutations	1182: Increase, Cell Proliferation (Epithelial Cells)	May 7, 2019	May 8, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1978	185: Increase, Mutations	870: Increase, Cell Proliferation	Aug 29, 2019	Mar 8, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1984	185: Increase, Mutations	1556: Increase, lung cancer	Aug 29, 2019	Jan 10, 2023	1 AOP 272: Deposition of energy leading to lung cancer

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