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Showing 2001 to 2025 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

706	714: Increased, Binding of chemicals to 2u (serum)	708: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)	Nov 29, 2016	Dec 3, 2016	1 AOP 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
1135	1098: Increased, blood potassium concentration	1100: Occurrence, cardiac arrthymia	Nov 29, 2016	Dec 3, 2016	None
1140	1098: Increased, blood potassium concentration	1106: Occurrence, cardiac arrhythmia	Nov 29, 2016	Dec 3, 2016	3 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
3403	1098: Increased, blood potassium concentration	1983: Disruption in action potential generation	Nov 20, 2024	Nov 20, 2024	1 AOP 551: Increased Muscarinic M2 Receptor leading to Arrhythmia
1132	1096: Increased, blood uric acid concentration	1102: Occurrence, tophi (urate) deposition	Nov 29, 2016	Dec 3, 2016	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
3263	1096: Increased, blood uric acid concentration	1392: Increase, Oxidative Stress	Jul 3, 2024	Jul 3, 2024	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
3291	2238: Increased, Blood viscosity	2239: Increased, Cardiac stress	Jul 8, 2024	Dec 3, 2024	1 AOP 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
703	699: Increased, cardiac arrthymia	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	1 AOP 104: Altered ion channel activity leading impaired heart function
3292	2239: Increased, Cardiac stress	1535: Heart failure	Jul 8, 2024	Dec 3, 2024	1 AOP 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
885	863: Increased, Catabolism of Muscle Protein	864: Decreased, Body Weight	Nov 29, 2016	Jun 11, 2018	1 AOP 6: Antagonist binding to PPARα leading to body-weight loss
1130	1089: Increased, Cell Proliferation (mesothelium)	1090: Increased, mesotheliomas	Nov 29, 2016	Dec 3, 2016	1 AOP 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1099	1062: Increased, Cellular proliferation / hyperplasia of acinar cells	1063: Increased, Pancreatic acinar tumors	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
758	761: Increased, Chloride conductance	763: hyperpolarisation, neuron	Nov 29, 2016	Dec 3, 2016	1 AOP 113: Glutamate-gated chloride channel activation leading to acute mortality
1052	761: Increased, Chloride conductance	1015: Increased, Neuronal synaptic inhibition	Nov 29, 2016	Dec 3, 2016	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
1047	1011: Increased, Chloride influx	1012: Increased, Inhibitory postsynaptic potential	Nov 29, 2016	Dec 3, 2016	None
1100	1059: Increased, cholestasis	1061: prolonged, elevation of serun CCK	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
3368	2270: Increased, cholesterol synthesis enzymes	2271: Increased, plasma LDL cholesterol	Oct 22, 2024	Feb 10, 2025	1 AOP 545: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis
700	696: Increased, Chromosome misseggregation	675: Reduced, Reproductive Success	Nov 29, 2016	Dec 3, 2016	1 AOP 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
1210	1162: Increased, cilia movement	1146: premature, Spawning	Nov 29, 2016	Dec 3, 2016	None
1329	1162: Increased, cilia movement	1255: induced spawning	Jan 17, 2017	Jan 17, 2017	None
1113	1076: Increased, circulating estrogen levels	1078: Hyperplasia, Mammary gland	Nov 29, 2016	Dec 3, 2016	1 AOP 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1119	1076: Increased, circulating estrogen levels	1081: Increased, lactotroph hyperplasia and hypertrophy	Nov 29, 2016	Dec 3, 2016	1 AOP 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
2584	1076: Increased, circulating estrogen levels	1051: Hyperplasia, ovarian stromal cells	Feb 26, 2022	Mar 2, 2022	None
2585	1076: Increased, circulating estrogen levels	1052: Hyperplasia, ovarian epithelium	Feb 26, 2022	Mar 2, 2022	1 AOP 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
3437	1076: Increased, circulating estrogen levels	2294: Plasma E2, increased	Nov 22, 2024	Nov 22, 2024	1 AOP 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol

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