Prototypical Stressors

Showing 626 to 650 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

196	coumachlor	Coumachlor, CAS-RN: 81-82-3, DTXSID8041797	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
332	Colistin	Colistin, CAS-RN: 1066-17-7, DTXSID1040663	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
124	Colchicine	Colchicine, CAS-RN: 64-86-8, DTXSID5024845	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
510	colchemid		None
511	Colcemid	Colcemid, CAS-RN: 477-30-5, DTXSID7020342	None
292	Clotrimazole	Clotrimazole, CAS-RN: 23593-75-1, DTXSID7029871	None
262	Clonixin	Clonixin, CAS-RN: 17737-65-4, DTXSID2046121	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
734	Clomiphene citrate (1:1)	Clomiphene citrate (1:1), CAS-RN: 50-41-9, DTXSID8020337	440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
735	Clomiphene	Clomiphene, CAS-RN: 911-45-5, DTXSID1022843	None
191	Clofibrate	Clofibrate, CAS-RN: 637-07-0, DTXSID3020336	3 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
463	Citral		297: Inhibition of retinaldehyde dehydrogenase leads to population decline
406	CITCO	CITCO, CAS-RN: 338404-52-7, DTXSID4040761	None
716	Cisplatin	Cisplatin, CAS-RN: 15663-27-1, DTXSID4024983	472: DNA adduct formation leading to kidney failure
707	Cisapride	Cisapride, CAS-RN: 81098-60-4, DTXSID3022825	2 AOPs 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
391	Ciprofloxacin	Ciprofloxacin, CAS-RN: 85721-33-1, DTXSID8022824	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
207	ciprofibrate	Ciprofibrate, CAS-RN: 52214-84-3, DTXSID8020331	37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
488	cinnamic aldehyde		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
831	Cilobradine		562: HCN Channel Inhibition leading to Arrhythmias
645	Cigarette smoke	Cigarette smoke, CAS-RN: NOCAS, DTXSID5035038	5 AOPs 403: combined unhealthy lifestyle factors leading to metabolic syndrome 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
326	Cidofovir	Cidofovir, CAS-RN: 113852-37-2, DTXSID3043734	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
713	Chromium	Chromium, CAS-RN: 7440-47-3, DTXSID3031022	None
243	Chromafenozide	Chromafenozide, CAS-RN: 143807-66-3, DTXSID4057976	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
787	Cholinergic drugs		551: Increased Muscarinic M2 Receptor leading to Arrhythmia
680	Cholesterol	Cholesterol, CAS-RN: 57-88-5, DTXSID3022401	None
356	Chlorzoxazone	Chlorzoxazone, CAS-RN: 95-25-0, DTXSID9022813	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration