Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1051 to 1075 of 1145 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
95 morphological change male reproductive organ (UBERON:0003135) 348: Malformation, Male reproductive tract
94 decreased testosterone (CHEBI:17347)
93 decreased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347)
92 decreased mitochondrial transport (GO:0006839) cholesterol (CHEBI:16113) 447: Reduction, Cholesterol transport in mitochondria
91 decreased gene expression (GO:0010467) translocator protein (PR:000016757) 289: Decrease, Translocator protein (TSPO)
90 decreased gene expression (GO:0010467) STAR (PR:000015715) 266: Decrease, Steroidogenic acute regulatory protein (STAR)
89 increased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor alpha (PR:000013056) 227: Activation, PPARĪ±
88 increased neuron death in response to oxidative stress (GO:0036475) 191: Neuronal dysfunction
87 occurrence oxidative stress (MP:0003674) None
86 decreased glutathione (CHEBI:16856) None
85 disrupted protein domain specific binding (GO:0019904) 158: N/A, Interferences with SH-/selen-proteins
84 occurrence protein binding (GO:0005515) Selenium-Binding Proteins (MESH:D051137) 261: Binding, SH-/selen-proteins
83 decreased population growth rate (PCO:0000008)
82 increased paralysis (MP:0000753)
81 increased hyperactivity (MP:0001399)
80 increased ataxia (MP:0001393)
79 increased respiratory distress (MP:0001954) 445: Respiratory distress/arrest
78 increased decreased heart rate (MESH:D001919) 444: Increased, Atrioventricular block and bradycardia
77 increased atrioventricular block (MESH:D054537) 444: Increased, Atrioventricular block and bradycardia
76 increased acetylcholine (CHEBI:15355) 10: Acetylcholine accumulation in synapses
75 decreased acetylcholinesterase activity (GO:0003990) acetylcholinesterase (PR:000003626) 12: Acetylcholinesterase (AchE) Inhibition
74 functional change DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) None
73 increased mutation (MESH:D009154) deoxyribonucleic acid (CHEBI:16991)
72 increased DNA alkylation (GO:0006305) deoxyribonucleic acid (CHEBI:16991) 97: Alkylation, DNA
71 increased Disease Susceptibility (MESH:D004198) 323: Increased, Disease susceptibility