Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 151 to 175 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
151 increased erythrocyte (CL:0000232)
152 increased liver vascular congestion (MP:0010019) 246: Increase, RBC congestion in liver
153 increased hemosiderosis (MESH:D006486) 161: Increase, Liver and splenic hemosiderosis
154 increased Methemoglobinemia (MESH:D008708) 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
155 decreased hemoglobin (CHEBI:35143) 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
156 occurrence Cyanosis (MESH:D003490) 321: N/A, Cyanosis occurs
157 increased metabolic process (GO:0008152) thiamethoxam (CHEBI:39185) 77: Production, Critical Metabolites (CGA 330050 and CGA 265307)
158 increased metabolic process (GO:0008152) metabolite (CHEBI:25212) 77: Production, Critical Metabolites (CGA 330050 and CGA 265307)
159 decreased Decreased liver function (HP:0001410) 164: Induction, Liver “Dysfunctional” Changes by CGA 330050
160 decreased nitric-oxide synthase activity (GO:0004517) nitric oxide synthase, brain (PR:000011326) 147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307
161 increased hepatotoxicity (MI:2141) 270: Induction, Sustained Hepatotoxicity
162 increased hepatocyte proliferation (GO:0072574) 269: Induction, Sustained Cell Proliferation
163 increased hepatocellular carcinoma (MESH:D006528)
164 increased signaling (GO:0023052) 5-hydroxytryptamine receptor 2C (PR:000001168) 9: Activation, 5HT2c
165 increased kidney failure (MP:0003606) 759: Increased, Kidney Failure
166 increased signaling (GO:0023052) oxysterols receptor LXR-beta (PR:000011394) 167: Activation, LXR
167 increased signaling (GO:0023052) oxysterols receptor LXR-alpha (PR:000011395)
168 increased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor gamma (PR:000013058) 228: peroxisome proliferator activated receptor promoter demethylation
169 increased gene expression (GO:0010467) platelet glycoprotein 4 (PR:000001905) 54: Up Regulation, CD36
170 increased positive regulation of fatty acid transport (GO:2000193) fatty acid (CHEBI:35366) 115: Increase, Fatty acid influx
171 increased signaling (GO:0023052) carbohydrate-responsive element-binding protein (PR:000010460) 66: Activation, ChREBP
172 increased SREBP signaling pathway (GO:0032933) sterol regulatory element-binding protein 1 (PR:000015611)
173 increased fatty acid synthase activity (GO:0004312) fatty acid synthase (PR:000007348) 116: Activation, FAS
174 increased gene expression (GO:0010467) acyl-CoA desaturase (PR:000014497)
175 increased fatty acid biosynthetic process (GO:0006633) fatty acid (CHEBI:35366)