AOP-Wiki

API

All Key Events

Showing 351 to 375 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

685	Reduced, Prostaglandins, ovary Short Name Reduced, Prostaglandins, ovary	1	Organ	Nov 29, 2016	Sep 16, 2017	63: Cyclooxygenase inhibition leading to reproductive dysfunction
687	Reduced, Prostaglandin E2 concentration, hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
689	Reduced, Gonadotropin releasing hormone, hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
690	Reduced, Luteinizing hormone (LH), plasma Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
691	Reduced, Maturation inducing steroid, plasma Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
692	Reduced, Maturation inducing steroid receptor signalling, oocyte Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
693	Increased, cyclic adenosine monophosphate Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 558: Phosphodiesterase inhibition leading to heart failure
694	Reduced, Meiotic prophase I/metaphase I transition, oocyte Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
695	Upregulated, Spindle assembly checkpoint protein Mad2-oocyte Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
696	Increased, Chromosome misseggregation Short Name Increased, Chromosome misseggregation	1	Cellular	Nov 29, 2016	Sep 16, 2017	103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
697	impaired, ion channels Short Name impaired, ion channels	2	Cellular	Nov 29, 2016	Dec 3, 2016	104: Altered ion channel activity leading impaired heart function
698	Altered, Action Potential Short Name Altered, Action Potential	1	Cellular	Nov 29, 2016	Mar 31, 2022	4 AOPs 104: Altered ion channel activity leading impaired heart function 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
699	Increased, cardiac arrthymia Short Name Increased, cardiac arrthymia	1	Organ	Nov 29, 2016	Sep 16, 2017	104: Altered ion channel activity leading impaired heart function
708	Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
709	Increase, Cytotoxicity (renal tubular cell) Short Name	1	Cellular	Nov 29, 2016	Mar 3, 2022	5 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 258: Renal protein alkylation leading to kidney toxicity 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
710	Increase, Regenerative cell proliferation (tubular epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
713	Increase, Adenomas/carcinomas (renal tubular) Short Name	3	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
714	Increased, Binding of chemicals to 2u (serum) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
715	Activation, Constitutive androstane receptor Short Name	1	Molecular	Nov 29, 2016	Jun 28, 2018	107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
716	Increase, cell proliferation (hepatocytes) Short Name	2	Cellular	Nov 29, 2016	Jan 6, 2021	3 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
718	Binding, Tubulin Short Name Binding, Tubulin	2	Molecular	Nov 29, 2016	Apr 20, 2021	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
719	Increase, hepatocellular adenomas and carcinomas Short Name	3	Tissue	Nov 29, 2016	Dec 26, 2020	5 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
720	Disruption, Microtubule dynamics Short Name Disruption, Microtubule dynamics	1	Molecular	Nov 29, 2016	Nov 7, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
721	Disorganization, Meiotic Spindle Short Name Disorganization, Meiotic Spindle	1	Cellular	Nov 29, 2016	Apr 20, 2021	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
723	Altered, Chromosome number Short Name Altered, Chromosome number	1	Cellular	Nov 29, 2016	May 27, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring