AOP-Wiki

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All Key Events

Showing 1426 to 1450 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1918	Increased，Myocardial apoptosis Short Name Increased，Myocardial apoptosis	0	Cellular	Aug 18, 2021	Sep 1, 2021	None
1919	Increased，Cardiac Dysregulation Short Name Increased，Cardiac dysfunction	0	Tissue	Aug 18, 2021	Sep 1, 2021	None
1920	Altered gene expression, TGF-β dependent fibrosis pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway
1921	Altered gene expression, NF-kB dependent Interleukin-6 pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	2 AOPs 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
1922	Increased, Reactive metabolites production Short Name Increased, metabolites	0	Cellular	Aug 19, 2021	Aug 26, 2021	417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway
1923	Altered gene expression, P53 dependent apoptosis pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway
1924	Increased，Cardiac fibrosis Short Name Increased，Cardiac fibrosis	0	Organ	Aug 19, 2021	Sep 1, 2021	550: Increased LMNA gene mutation leading to heart failure
1925	Increased，Vascular smooth muscle cell activation Short Name	0	Cellular	Aug 19, 2021	Sep 1, 2021	None
1926	Increased，Vascular fibrosis Short Name Increased，Vascular fibrosis	0	Tissue	Aug 19, 2021	Sep 1, 2021	None
1927	Increased，Vascular endothelial cell autophagy dysfunction Short Name	0	Cellular	Aug 19, 2021	Sep 1, 2021	None
1928	increased，Vascular endothelial dysfunction Short Name	0	Tissue	Aug 19, 2021	Sep 1, 2021	6 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
1929	Increased incidence of cardiovascular morbidity and mortality in the general population Short Name	0	Population	Aug 21, 2021	Aug 21, 2021	519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
1930	altered, inner ear development Short Name Altered, inner ear development	1	Organ	Aug 23, 2021	Aug 24, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1931	Intestinal barrier, disruption Short Name Disruption of the intestinal barrier	1	Organ	Sep 1, 2021	Apr 27, 2025	3 AOPs 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
1932	Gastrointestinal disorders Short Name GI disorders	0	Individual	Sep 2, 2021	Sep 8, 2021	None
1933	Increased, Interleukin-6 production Short Name Increased IL-6 production	0	Cellular	Sep 20, 2021	Sep 20, 2021	416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
1934	Myocardial Infarction Short Name Heart attack	0	Organ	Oct 15, 2021	Oct 15, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1935	Angiotensin (1-7) levels diminished Short Name Ang (1-7) levels reduced	0	Molecular	Oct 15, 2021	Oct 15, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1936	Angiotensin II degradation reduced Short Name Degradation of Ang-II reduced	0	Molecular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1937	ADAM17 expression induction Short Name ADAM17 induction	0	Cellular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1938	ACE2 increased shedding Short Name ACE2 increased shedding	0	Molecular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1939	Viral infection and host-to-host transmission, proliferated Short Name Viral infection, proliferated	1	Individual	Oct 24, 2021	Jun 29, 2024	430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
1941	Memory Loss Short Name Memory Loss	0	Individual	Oct 26, 2021	Oct 26, 2021	429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
1942	Accumulation, Cytosolic toxic Tau oligomers Short Name Accumulation, Toxic Tau oligomers	0	Cellular	Oct 26, 2021	Oct 26, 2021	429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
1943	Hyperphosphorylation of Tau Short Name p-Tau	0	Cellular	Oct 26, 2021	Oct 26, 2021	429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants