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All Key Events

Showing 551 to 575 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1883	Decreased, size of the ovarian reserve Short Name Decreased, ovarian reserve	1	Organ	May 24, 2021	Jul 27, 2025	2 AOPs 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
1882	Disrupted, initiation of meiosis of oogonia in the ovary Short Name Disrupted, meiotic initiation in oocyte	1	Cellular	May 24, 2021	Jul 4, 2025	398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia
1881	Decreased, all-trans retinoic acid (atRA) concentration Short Name Decreased, atRA concentration	1	Tissue	May 24, 2021	Feb 13, 2023	2 AOPs 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1880	Decreased, ALDH1A (RALDH) enzyme activity Short Name Decreased, ALDH1A activity	1	Molecular	May 24, 2021	Dec 17, 2024	2 AOPs 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1879	Bulky DNA adducts, increase Short Name Bulky DNA adducts, increase	1	Molecular	May 17, 2021	May 17, 2021	2 AOPs 397: Bulky DNA adducts leading to mutations 644: Bulky DNA adducts leading to chromosomal aberrations and mutations
1878	Decreased, Eye size Short Name Decreased, Eye size	1	Organ	May 11, 2021	Jun 24, 2021	2 AOPs 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
1877	Altered, retinal layer structure Short Name Altered, retinal layer structure	1	Tissue	May 11, 2021	Jul 8, 2022	363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
1876	ACE2 shedding effects on viral entry Short Name Hyunjoon Kong	0	Cellular	Apr 28, 2021	Apr 28, 2021	None
1875	Cerebrovascular disease (stroke) Short Name stroke	0	Organ	Apr 27, 2021	Mar 30, 2022	395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
1874	blood brain barrier disruption Short Name BBB disruption	0	Cellular	Apr 27, 2021	Apr 27, 2021	395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
1873	impaired olfactory function (anosmia) Short Name anosmia	0	Organ	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1872	Olfactory epithelium degeneration Short Name Olfactory epithelium degeneration	0	Tissue	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1871	olfactory sensory neurons, decrease Short Name olfacotry neurons, decrease	0	Cellular	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1870	Sustentacular cells, decrease Short Name Sustentacular cells, decrease	0	Cellular	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1869	Diminished protective oxidative stress response Short Name Diminished Protective Response to ROS	3	Cellular	Apr 20, 2021	Oct 30, 2023	5 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 488: Increased reactive oxygen species production leading to decreased cognitive function
1868	Hyperinflammation Short Name Hyperinflammation	10	Tissue	Apr 20, 2021	Dec 29, 2021	4 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 406: SARS-CoV-2 infection leading to hyperinflammation 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1867	Bradykinin system, hyperactivated Short Name Bradykinin, activated	3	Molecular	Apr 20, 2021	Jan 24, 2022	392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
1866	Fibrinolysis, decreased Short Name Hypofibrinolysis	2	Molecular	Apr 20, 2021	Oct 19, 2021	392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
1865	Increase, Oxygen-evolving complex damage Short Name Increase, OEC damage	0	Molecular	Apr 11, 2021	Apr 11, 2021	389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1864	Increase, Programmed cell death Short Name Increase, Programmed cell death	0	Cellular	Apr 11, 2021	Apr 12, 2021	388: Deposition of ionising energy leading to population decline via programmed cell death
1863	Decrease, Reproduction Short Name Decrease, Reproduction	0	Individual	Apr 11, 2021	Apr 11, 2021	9 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 435: Deposition of ionising energy leads to population decline via pollen abnormal 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 595: Emerging OPFRS reproductive outcome pathway
1862	Decrease, Photosystem II efficiency Short Name Decrease, Photosystem II efficiency	0	Cellular	Apr 11, 2021	Jan 16, 2026	3 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
1861	Increase, D1 protein deactivation Short Name D1 protein deactivation	0	Cellular	Apr 11, 2021	Apr 11, 2021	386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
1860	Increase, Excitation of intracellular water Short Name Excitation of intracellular water	0	Molecular	Apr 11, 2021	Apr 11, 2021	None
1859	Excitation of intracellular water Short Name Excitation of intracellular water	0	Molecular	Apr 11, 2021	Apr 11, 2021	None