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All Key Events

Showing 1051 to 1075 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1339	Increase, intracellular calcium Short Name Increase, intracellular calcium	1	Cellular	Apr 13, 2017	Jul 21, 2023	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
1338	Increase, inositol triphosphate Short Name Increase, inositol triphosphate	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1337	Activate, PLC (Phospholipase C) Short Name Activate, PLC	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1336	Activation, 5-HT2A (Serotonin 2A) Short Name Activation, 5-HT2A	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1335	Reduced, BDNF (Brain-derived neurotrophic factor) Short Name Reduced, BDNF	0	Molecular	Apr 13, 2017	Nov 10, 2025	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
1334	Increase, cortisone Short Name Increase, cortisone	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1333	Increase, mental stress Short Name Increase, mental stress	0	Individual	Apr 13, 2017	Apr 13, 2017	None
1332	Inhibit, depression Short Name Inhibit, depression	0	Individual	Apr 13, 2017	Apr 13, 2017	None
1331	Inhibit, agitation Short Name Inhibit, agitation	0	Individual	Apr 13, 2017	Apr 13, 2017	None
1330	Decreased, neuroplasticity Short Name Decreased, neuroplasticity	0	Molecular	Apr 13, 2017	Nov 10, 2025	6 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
1329	Reduce expression, BDNF (Brain-derived neurotrophic factor) Short Name Reduce expression, BDNF	0	Molecular	Apr 13, 2017	May 31, 2017	5 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
1328	Inactivated, 5-HTR (serotonin receptors) Short Name Inactivated, 5-HTR	0	Molecular	Apr 13, 2017	May 31, 2017	5 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
1327	Decreased, seizure Short Name Decreased, seizure	0	Individual	Apr 13, 2017	Apr 13, 2017	None
1326	Increased, 5-HT3 (5-hydroxytryptamine) Short Name Increased, 5-HT3	0	Molecular	Apr 13, 2017	Jun 1, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1325	Decreased, synaptic release Short Name Decreased, synaptic release	0	Molecular	Apr 13, 2017	May 31, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1324	Decreased, packaged serotonin Short Name Decreased, packaged serotonin	0	Molecular	Apr 13, 2017	May 31, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1323	Decreased, intracellular serotonin Short Name Decreased, intracellular serotonin	0	Molecular	Apr 13, 2017	May 31, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1322	Increased, intracellular chloride (Cl-) Short Name Increased, intracellular chloride (Cl-)	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 215: Molecular events lead to epilepsy
1321	Increased, intracellular sodium (Na+) Short Name Increased, intracellular sodium (Na+)	0	Molecular	Apr 13, 2017	Apr 13, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 556: Decreased Na/K ATPase activity leading to heart failure
1320	Increased, extracellular serotonin Short Name Increased, extracellular serotonin	2	Molecular	Apr 13, 2017	Feb 13, 2025	8 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
1319	Decreased, extracellular chloride (Cl-) Short Name Decreased, extracellular chloride (Cl-)	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1318	Decreased, extracellular sodium (Na+) Short Name Decreased, extracellular Na+	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1317	Decreased, serotonin transporter activity Short Name	0	Molecular	Apr 13, 2017	May 31, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1316	Inhibit, serotonin transporter activity Short Name Inhibit, serotonin transporter activity	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1315	Increase, Selective Serotonin Reuptake Inhibitors (SSRIs) Short Name Increase, SSRIs	0	Molecular	Apr 13, 2017	Apr 13, 2017	None