AOP-Wiki

API

All Key Events

Showing 1176 to 1200 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1210	Alteration, Food-web structures Short Name Alteration, Food-web structures	1	Population	Nov 29, 2016	Dec 3, 2016	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1209	Induction, Male reproductive tract Short Name Induction, Male reproductive tract	1	Organ	Nov 29, 2016	Sep 16, 2017	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1208	Increased, Male offspring Short Name Increased, Male offspring	2	Population	Nov 29, 2016	Dec 3, 2016	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1207	Induction, Male traits formation in embryos Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1206	Induction, Doublesex1 gene Short Name Induction, Doublesex1 gene	1	Molecular	Nov 29, 2016	Sep 16, 2017	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1205	Activation, Juvenile hormone receptor Short Name Activation, Juvenile hormone receptor	1	Molecular	Nov 29, 2016	Sep 16, 2017	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1204	Suppression, Suppression of T-cell dependent antibody production Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
1203	Suppression, Suppression of production of cytotoxic T-cells Short Name	0	Tissue	Nov 29, 2016	Dec 3, 2016	None
1202	Suppression, IL-2 and IL-4 production Short Name Suppression, IL-2 and IL-4 production	2	Cellular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
1201	Binding, Immunophilins Short Name Binding, Immunophilins	1	Molecular	Nov 29, 2016	Oct 17, 2017	None
1200	Binding of FK506 to FKBP12, Formation Short Name Binding of FK506 to FKBP12, Formation	0		Nov 29, 2016	Nov 29, 2016	None
1199	Binding of FK506 to FKBP12, Short Name Binding of FK506 to FKBP12,	0		Nov 29, 2016	Nov 29, 2016	None
1198	Activation, Macrophages Short Name Activation, Macrophages	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 200: Estrogen receptor activation leading to breast cancer 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. 462: Activation of reactive oxygen species leading the atherosclerosis
1197	Activation, Fibroblasts Short Name Activation, Fibroblasts	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 200: Estrogen receptor activation leading to breast cancer 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
1196	Increased, Invasion Short Name Increased, Invasion	1	Cellular	Nov 29, 2016	Feb 29, 2024	3 AOPs 200: Estrogen receptor activation leading to breast cancer 439: Activation of the AhR leading to metastatic breast cancer 495: Androgen receptor activation leading to prostate cancer
1195	modulation, Extracellular Matrix Composition Short Name	1	Cellular	Nov 29, 2016	Jun 4, 2026	2 AOPs 200: Estrogen receptor activation leading to breast cancer 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
1194	Increase, DNA damage Short Name Increase, DNA Damage	1	Molecular	Nov 29, 2016	May 8, 2019	14 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 396: Deposition of ionizing energy leads to population decline via impaired meiosis 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 388: Deposition of ionising energy leading to population decline via programmed cell death 435: Deposition of ionising energy leads to population decline via pollen abnormal 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration 472: DNA adduct formation leading to kidney failure 645: Binding and activation of AhR lead to cardiovascular aging
1193	N/A, Breast Cancer Short Name N/A, Breast Cancer	1	Individual	Nov 29, 2016	Feb 29, 2024	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1192	Increased, Ductal Hyperplasia Short Name Increased, Ductal Hyperplasia	1	Tissue	Nov 29, 2016	Sep 16, 2017	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1191	Increased, Non-genomic signaling Short Name Increased, Non-genomic signaling	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1190	Increased, Migration (Endothelial Cells) Short Name	1	Cellular	Nov 29, 2016	Feb 29, 2024	2 AOPs 200: Estrogen receptor activation leading to breast cancer 439: Activation of the AhR leading to metastatic breast cancer
1189	Increased, Proliferation (Endothelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1188	Increased, ER binding to T.F. to DNA (non-classical pathway) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1187	Increased, ER binding to DNA (classical pathway) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1184	Dysfunction, Mitochondrial Dynamics Short Name Dysfunction, Mitochondrial Dynamics	0		Nov 29, 2016	Nov 29, 2016	None