AOP-Wiki

API

All Key Events

Showing 1626 to 1650 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

637	impaired, Learning and memory Short Name impaired, Learning and memory	0	Individual	Nov 29, 2016	Dec 3, 2016	471: Neuron defect induced early behavioral change
636	Decreased, survival Short Name Decreased, survival	1	Population	Nov 29, 2016	Dec 3, 2016	2 AOPs 99: Histamine (H2) receptor antagonism leading to reduced survival 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
635	Decreased, locomotion Short Name Decreased, locomotion	1	Individual	Nov 29, 2016	Dec 3, 2016	99: Histamine (H2) receptor antagonism leading to reduced survival
634	N/A, sedation Short Name N/A, sedation	1	Individual	Nov 29, 2016	Dec 3, 2016	99: Histamine (H2) receptor antagonism leading to reduced survival
633	Decrease, histaminergic neuron excitation Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	99: Histamine (H2) receptor antagonism leading to reduced survival
629	Decreased, sheltering Short Name Decreased, sheltering	1	Individual	Nov 29, 2016	Dec 3, 2016	98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
627	Decreased, anxiety Short Name Decreased, anxiety	1	Individual	Nov 29, 2016	Dec 3, 2016	98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
626	Increased, serotonin (5-HT) Short Name Increased, serotonin (5-HT)	1	Cellular	Nov 29, 2016	Sep 16, 2017	5 AOPs 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
625	Increased, muscular waves in foot Short Name Increased, muscular waves in foot	0	Organ	Nov 29, 2016	Sep 16, 2017	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
624	Increased, foot detachment Short Name Increased, foot detachment	1	Individual	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
623	Increase, predation Short Name Increase, predation	1	Population	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
622	Increased, locomotion Short Name Increased, locomotion	1	Individual	Nov 29, 2016	Dec 3, 2016	97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
621	Increase, cilia movement Short Name Increase, cilia movement	0	Tissue	Nov 29, 2016	Jan 13, 2017	3 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
620	Increased, serotonin (5-HT) 1 1 Short Name Increased, serotonin (5-HT) 1	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
619	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Short Name	2	Molecular	Nov 29, 2016	Feb 24, 2025	6 AOPs 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
618	Decreased, Neuronal network function in adult brain Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	3 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Neuron defect induced early behavioral change
616	Occurrence, A paroxysmal depolarizing shift Short Name	1	Tissue	Nov 29, 2016	Apr 29, 2019	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
613	Occurrence, Epileptic seizure Short Name Occurrence, Epileptic seizure	1	Individual	Nov 29, 2016	Apr 29, 2019	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
602	Increased, Ataxia, paralysis, or hyperactivity Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	2 AOPs 96: Axonal sodium channel modulation leading to acute mortality 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
601	Overactivation, muscle contraction Short Name Overactivation, muscle contraction	1	Tissue	Nov 29, 2016	Sep 16, 2017	96: Axonal sodium channel modulation leading to acute mortality
600	Overactivation, Neuronotransmitter release Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	96: Axonal sodium channel modulation leading to acute mortality
599	prolonged, Depolarization of neuronal membrane Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	96: Axonal sodium channel modulation leading to acute mortality
598	modulation, sodium channel Short Name modulation, sodium channel	1	Molecular	Nov 29, 2016	Sep 16, 2017	96: Axonal sodium channel modulation leading to acute mortality
593	Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	2 AOPs 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
592	Reduced, survival Short Name Reduced, survival	1	Population	Nov 29, 2016	Dec 3, 2016	2 AOPs 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival