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All Key Events

Showing 726 to 750 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1169	Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin Short Name	2	Molecular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1170	Increase, Phenotypic enzyme activity Short Name Increase, Phenotypic enzyme activity	0	Cellular	Nov 29, 2016	Dec 28, 2020	37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
1171	Increase, Clonal Expansion of Altered Hepatic Foci Short Name	0	Cellular	Nov 29, 2016	Jan 6, 2021	37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
1172	Increased activation, Nuclear factor kappa B (NF-kB) Short Name	1	Cellular	Nov 29, 2016	Aug 27, 2023	5 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 319: Binding to ACE2 leading to lung fibrosis 443: DNA damage and mutations leading to Metastatic Breast Cancer 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
1173	Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids Short Name	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
1174	Activation, NADPH Oxidase Short Name Activation, NADPH Oxidase	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
1175	Increase, Genes involved in fatty acid oxidation Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
1176	Decreased, sodium conductance 2 Short Name Decreased, sodium conductance 2	1	Cellular	Nov 29, 2016	Dec 3, 2016	197: Sodium channel (Nav1.1) inhibition leading to population decline
1177	Decreased, Ionotropic GABA receptor chloride channel conductance Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	471: Neuron defect induced early behavioral change
1178	Decreased, Chloride conductance Short Name Decreased, Chloride conductance	0		Nov 29, 2016	Nov 29, 2016	None
1179	Decreased, GABA release Short Name Decreased, GABA release	1	Cellular	Nov 29, 2016	Dec 3, 2016	197: Sodium channel (Nav1.1) inhibition leading to population decline
1180	Estrogen receptor activation, Short Name Estrogen receptor activation,	0		Nov 29, 2016	Nov 29, 2016	None
1182	Increase, Cell Proliferation (Epithelial Cells) Short Name	1	Cellular	Nov 29, 2016	May 8, 2019	3 AOPs 200: Estrogen receptor activation leading to breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1183	Decreased, Apoptosis (Epithelial Cells) Short Name Decreased, Apoptosis (Epithelial Cells)	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 200: Estrogen receptor activation leading to breast cancer 495: Androgen receptor activation leading to prostate cancer
1184	Dysfunction, Mitochondrial Dynamics Short Name Dysfunction, Mitochondrial Dynamics	0		Nov 29, 2016	Nov 29, 2016	None
1187	Increased, ER binding to DNA (classical pathway) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1188	Increased, ER binding to T.F. to DNA (non-classical pathway) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1189	Increased, Proliferation (Endothelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1190	Increased, Migration (Endothelial Cells) Short Name	1	Cellular	Nov 29, 2016	Feb 29, 2024	2 AOPs 200: Estrogen receptor activation leading to breast cancer 439: Activation of the AhR leading to metastatic breast cancer
1191	Increased, Non-genomic signaling Short Name Increased, Non-genomic signaling	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1192	Increased, Ductal Hyperplasia Short Name Increased, Ductal Hyperplasia	1	Tissue	Nov 29, 2016	Sep 16, 2017	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1193	N/A, Breast Cancer Short Name N/A, Breast Cancer	1	Individual	Nov 29, 2016	Feb 29, 2024	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1194	Increase, DNA damage Short Name Increase, DNA Damage	1	Molecular	Nov 29, 2016	May 8, 2019	12 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 396: Deposition of ionizing energy leads to population decline via impaired meiosis 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 388: Deposition of ionising energy leading to population decline via programmed cell death 435: Deposition of ionising energy leads to population decline via pollen abnormal 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
1195	modulation, Extracellular Matrix Composition Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1196	Increased, Invasion Short Name Increased, Invasion	1	Cellular	Nov 29, 2016	Feb 29, 2024	3 AOPs 200: Estrogen receptor activation leading to breast cancer 439: Activation of the AhR leading to metastatic breast cancer 495: Androgen receptor activation leading to prostate cancer