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Showing 2651 to 2675 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

990	920: Goblet cell metaplasia	943: Hypersecretion, Mucus	Nov 29, 2016	Nov 29, 2016	None
1313	920: Goblet cell metaplasia	962: Increase, Mucin production	Nov 29, 2016	Aug 11, 2021	None
2471	920: Goblet cell metaplasia	1251: Chronic, Mucus hypersecretion	Aug 26, 2021	Aug 27, 2021	None
1139	1105: Occurrence, renal ischemia	1097: Occurrence, renal proximal tubular necrosis	Nov 29, 2016	Dec 3, 2016	None
3265	1105: Occurrence, renal ischemia	1392: Increase, Oxidative Stress	Jul 3, 2024	Jul 3, 2024	1 AOP 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1134	1097: Occurrence, renal proximal tubular necrosis	1098: Increased, blood potassium concentration	Nov 29, 2016	Dec 3, 2016	3 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
1156	1097: Occurrence, renal proximal tubular necrosis	1096: Increased, blood uric acid concentration	Nov 29, 2016	Dec 3, 2016	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
2647	1097: Occurrence, renal proximal tubular necrosis	814: Occurrence, Kidney toxicity	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
1133	1102: Occurrence, tophi (urate) deposition	1097: Occurrence, renal proximal tubular necrosis	Nov 29, 2016	Dec 3, 2016	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
943	919: Occurrence, Transdifferentiation of ciliated epithelial cells	920: Goblet cell metaplasia	Nov 29, 2016	Aug 11, 2021	None
2364	1872: Olfactory epithelium degeneration	1873: anosmia	Apr 26, 2021	Apr 26, 2021	1 AOP 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
2363	1871: olfacotry neurons, decrease	1872: Olfactory epithelium degeneration	Apr 26, 2021	Apr 26, 2021	1 AOP 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
2366	1871: olfacotry neurons, decrease	1873: anosmia	Apr 26, 2021	Apr 26, 2021	1 AOP 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
3572	2340: Oligomerisation of DLAT, increased	2341: TCA cycle, disrupted	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
3577	2340: Oligomerisation of DLAT, increased	889: Proteostasis, impaired	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
1272	1218: Opening of calcium channel, Calcium influx	1217: Sensory Airway Irritation	Nov 29, 2016	Dec 3, 2016	None
1274	1218: Opening of calcium channel, Calcium influx	1220: Excitation, Trigeminal nerve excitation	Nov 29, 2016	Dec 3, 2016	1 AOP 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1280	1218: Opening of calcium channel, Calcium influx	1222: SP (Substance P) release, Local increase of SP	Nov 29, 2016	Nov 29, 2016	None
1565	1427: Opening of GIRK channels	763: hyperpolarisation, neuron	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
3040	2187: Opening VGCCs	389: Increased, Intracellular Calcium overload	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3534	2323: Over-expression of PD-L1 in cancer cells	2324: Dysregulation of Treg/Th17 cell ratio	May 16, 2025	Feb 25, 2026	1 AOP 578: AhR activation leading to cancer progression via immunosuppression
606	601: Overactivation, muscle contraction	602: Increased, Ataxia, paralysis, or hyperactivity	Nov 29, 2016	Dec 3, 2016	1 AOP 96: Axonal sodium channel modulation leading to acute mortality
605	600: Overactivation, Neuronotransmitter release	601: Overactivation, muscle contraction	Nov 29, 2016	Dec 3, 2016	1 AOP 96: Axonal sodium channel modulation leading to acute mortality
361	388: Overactivation, NMDARs	389: Increased, Intracellular Calcium overload	Nov 29, 2016	Sep 10, 2023	4 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
2781	388: Overactivation, NMDARs	1788: Status epilepticus	Oct 12, 2022	Sep 3, 2023	1 AOP 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration

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