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Showing 1401 to 1425 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2845	2090: Bone Remodeling	2091: Bone Loss	Jan 25, 2023	Aug 9, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
60	50: Increase, Ca++ (intracellular)	178: Mitochondrial electron transport chain, disrupted	Nov 29, 2016	Dec 3, 2016	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
3175	2084: Increase, Cardiac remodelling	2215: Decrease LV function	Apr 3, 2024	Apr 3, 2024	1 AOP 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
2103	1774: Increase, Casp transcription	1775: Increase, Oocyte apoptosis	Apr 30, 2020	Apr 30, 2020	2 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 338: DNA methyltransferase inhibition leading to population decline (3)
2105	1774: Increase, Casp transcription	1776: Increase, Ovarian somatic cell apoptosis	Apr 30, 2020	Apr 30, 2020	1 AOP 337: DNA methyltransferase inhibition leading to population decline (2)
2112	1779: Increase, Casp transcription (F3)	1780: Increase, Oocyte apoptosis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 340: DNA methyltransferase inhibition leading to transgenerational effects (1)
2116	1779: Increase, Casp transcription (F3)	1783: Increase, Ovarian somatic cell apoptosis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
2215	1825: Increase, Cell death	1521: Decrease, Growth	Dec 4, 2020	Dec 4, 2020	1 AOP 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
2467	1825: Increase, Cell death	1930: Altered, inner ear development	Aug 23, 2021	Aug 29, 2021	1 AOP 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
2489	1825: Increase, Cell death	1931: Disruption of the intestinal barrier	Oct 19, 2021	Oct 19, 2021	None
2706	1825: Increase, Cell death	896: Parkinsonian motor deficits	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2718	1825: Increase, Cell death	188: Neuroinflammation	Jul 25, 2022	Jul 25, 2022	None
2760	1825: Increase, Cell death	1496: Increased proinflammatory mediators	Sep 1, 2022	Sep 1, 2022	1 AOP 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2842	1825: Increase, Cell death	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Nov 6, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2863	1825: Increase, Cell death	758: Hippocampal Physiology, Altered	Apr 3, 2023	Apr 3, 2023	None
3504	1825: Increase, Cell death	2312: Increased, nasal lesions	Mar 5, 2025	Mar 19, 2025	1 AOP 368: Cytochrome oxidase inhibition leading to increased nasal lesions
3507	1825: Increase, Cell death	2316: Increased, pulmonary edema	Mar 12, 2025	Mar 24, 2025	1 AOP 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema
3508	1825: Increase, Cell death	2317: Loss of olfactory function	Mar 13, 2025	Mar 25, 2025	1 AOP 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function
3765	1825: Increase, Cell death	1097: Occurrence, renal proximal tubular necrosis	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
67	55: Cell injury/death	134: Increase, Kupffer cell activation	Nov 29, 2016	Nov 29, 2016	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
68	55: Cell injury/death	265: Increase, HSC activation	Nov 29, 2016	Apr 21, 2026	2 AOPs 38: Protein Alkylation leading to Liver Fibrosis 494: AhR activation leading to liver fibrosis
355	55: Cell injury/death	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
364	55: Cell injury/death	352: N/A, Neurodegeneration	Nov 29, 2016	Sep 10, 2023	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
365	55: Cell injury/death	188: Neuroinflammation	Nov 29, 2016	Jul 15, 2022	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
924	55: Cell injury/death	87: Release, Cytokine	Nov 29, 2016	Nov 9, 2018	None

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