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Showing 1576 to 1600 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3725	2405: Increase, Hepatocellular lipotoxicity	177: Increase, Mitochondrial dysfunction	Feb 10, 2026	Feb 10, 2026	1 AOP 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction
3736	2405: Increase, Hepatocellular lipotoxicity	1815: Increase, ER stress	Feb 11, 2026	Feb 11, 2026	2 AOPs 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
3745	2405: Increase, Hepatocellular lipotoxicity	1392: Increase, Oxidative Stress	Feb 24, 2026	Feb 24, 2026	2 AOPs 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress
1994	1698: Increase, hypermethylation of the promotor region of GnRHR	1699: Decease, expression of GnRHR	Oct 30, 2019	Oct 30, 2019	1 AOP 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
743	740: Increase, Hyperplasia (follicular cells)	741: Increase, Adenomas/carcinomas (follicular cell)	Nov 29, 2016	Dec 3, 2016	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
783	782: Increase, Hyperplasia (forestomach epithelial cells)	779: Increase, Papillomas/carcinomas (squamous cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
771	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	773: Increase, Endometrial adenocarcinomas	Nov 29, 2016	Dec 3, 2016	1 AOP 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
2972	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	1896: Genomic instability	Jul 27, 2023	Mar 27, 2025	1 AOP 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
3608	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	1070: Increased, adenosquamous carcinomas of endometrium	Aug 26, 2025	Sep 18, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
731	744: Increase, Hyperplasia (Leydig cells)	745: Increase, Leydig cell tumors	Nov 29, 2016	Dec 3, 2016	2 AOPs 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
761	767: Increase, Hyperplasia (renal tubular cells)	713: Increase, Adenomas/carcinomas (renal tubular)	Nov 29, 2016	Dec 3, 2016	1 AOP 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
728	735: Increase, Hyperplasia (terminal bronchiolar cells)	736: Increase, Adenomas/carcinomas (bronchioloalveolar)	Nov 29, 2016	Dec 3, 2016	1 AOP 109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
786	784: Increase, Hyperplasia (tubular epithelial cells)	713: Increase, Adenomas/carcinomas (renal tubular)	Nov 29, 2016	Dec 3, 2016	1 AOP 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
798	796: Increase, Hyperplasia (urothelial)	797: Increase, Adenomas/carcinomas (urothelial)	Nov 29, 2016	Dec 3, 2016	1 AOP 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
2085	796: Increase, Hyperplasia (urothelial)	1763: carcinogenicity	Apr 21, 2020	Apr 21, 2020	1 AOP 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
1581	1343: Increase, hypertension	1226: Respiratory irritability	Jun 23, 2017	Jun 23, 2017	None
742	739: Increase, Hypertrophy and proliferation (follicular cell)	740: Increase, Hyperplasia (follicular cells)	Nov 29, 2016	Dec 3, 2016	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
2018	1707: Increase of IL-23	1708: Th17 cell migration and inflammation induction	Dec 27, 2019	Dec 27, 2019	1 AOP 313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1002	990: Increase, Incomplete ecdysis	350: Increase, Mortality	Nov 29, 2016	Dec 3, 2016	4 AOPs 466: Doda decarboxylase leading to mortality 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1190	990: Increase, Incomplete ecdysis	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	None
2750	990: Increase, Incomplete ecdysis	2056: Increase, delay in oviposition	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
2751	990: Increase, Incomplete ecdysis	2057: Decrease, hatching of egg	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
2759	990: Increase, Incomplete ecdysis	2050: Increase, developmental abnormalities	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
781	149: Increase, Inflammation	781: Increase, Regenerative cell proliferation (forestomach epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
929	149: Increase, Inflammation	357: Cholestasis, Pathology	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)

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