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Showing 2801 to 2825 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

126	111: Agonism, Estrogen receptor	363: Altered, Reproductive behaviour	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
127	111: Agonism, Estrogen receptor	364: Impaired development of, Reproductive organs	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
128	111: Agonism, Estrogen receptor	307: Increase, Vitellogenin synthesis in liver	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
3525	111: Agonism, Estrogen receptor	749: Decreased, Progesterone from corpus luteum	Apr 17, 2025	Apr 17, 2025	1 AOP 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
3528	111: Agonism, Estrogen receptor	1187: Increased, ER binding to DNA (classical pathway)	Apr 28, 2025	Apr 28, 2025	1 AOP 200: Estrogen receptor activation leading to breast cancer
3529	111: Agonism, Estrogen receptor	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	Apr 28, 2025	Apr 28, 2025	1 AOP 200: Estrogen receptor activation leading to breast cancer
3530	111: Agonism, Estrogen receptor	1191: Increased, Non-genomic signaling	Apr 28, 2025	Apr 28, 2025	1 AOP 200: Estrogen receptor activation leading to breast cancer
3531	111: Agonism, Estrogen receptor	1242: Increased, Second Messenger Production	Apr 28, 2025	Apr 28, 2025	1 AOP 200: Estrogen receptor activation leading to breast cancer
3560	111: Agonism, Estrogen receptor	1066: Promotion, SIX1 positive progenitor cells in endometrium	Aug 5, 2025	Aug 5, 2025	None
3561	111: Agonism, Estrogen receptor	2329: SIX1 gene expression, increased	Aug 5, 2025	Sep 12, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
31	25: Agonism, Androgen receptor	129: Reduction, Gonadotropins, circulating concentrations	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
32	25: Agonism, Androgen receptor	274: Reduction, Testosterone synthesis by ovarian theca cells	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
1384	25: Agonism, Androgen receptor	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Mar 17, 2017	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
1385	25: Agonism, Androgen receptor	285: Reduction, Vitellogenin synthesis in liver	Mar 17, 2017	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
2260	25: Agonism, Androgen receptor	1790: Increased, Differentiation to Testis	Jan 12, 2021	Jan 3, 2023	1 AOP 376: Androgen receptor agonism leading to male-biased sex ratio
2349	25: Agonism, Androgen receptor	1791: Increased, Male Biased Sex Ratio	Apr 12, 2021	Jan 3, 2023	1 AOP 376: Androgen receptor agonism leading to male-biased sex ratio
2926	25: Agonism, Androgen receptor	2139: Reduction, the ratio of E2/11-KT in plasma	May 22, 2023	May 22, 2023	None
3378	25: Agonism, Androgen receptor	2274: Androgen receptor activation, increased	Nov 2, 2024	Nov 24, 2024	1 AOP 547: Androgen receptor agonism leading to long anogenital distance in female offspring
3392	25: Agonism, Androgen receptor	286: Altered, Transcription of genes by the AR	Nov 16, 2024	Nov 16, 2024	2 AOPs 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 495: Androgen receptor activation leading to prostate cancer
3450	25: Agonism, Androgen receptor	716: Increase, cell proliferation (hepatocytes)	Dec 23, 2024	Dec 23, 2024	1 AOP 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
3462	25: Agonism, Androgen receptor	1599: Inflammatory events	Dec 31, 2024	Dec 31, 2024	1 AOP 495: Androgen receptor activation leading to prostate cancer
3463	25: Agonism, Androgen receptor	1183: Decreased, Apoptosis (Epithelial Cells)	Dec 31, 2024	Dec 31, 2024	1 AOP 495: Androgen receptor activation leading to prostate cancer
3645	2370: A1AR Agonism	2371: Increased cortisol	Oct 1, 2025	May 29, 2026	1 AOP 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
2696	2025: Affected folate transporter	2026: decrease folate	Jul 19, 2022	Jul 19, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
2523	1937: ADAM17 induction	1938: ACE2 increased shedding	Oct 28, 2021	Oct 28, 2021	None

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