Key Event Relationships (KERs)

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Showing 2826 to 2850 of 3164 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2157 1793: AP-1 activation 1795: TGFbeta expression Jul 9, 2020 Jul 9, 2020
301 272: Activation/Proliferation, T-cells 312: N/A, Allergic contact dermatitis on challenge Nov 29, 2016 Dec 3, 2016 None
835 272: Activation/Proliferation, T-cells 827: sensitisation, skin Nov 29, 2016 Dec 3, 2016
1701 272: Activation/Proliferation, T-cells 313: Increase, Allergic Respiratory Hypersensitivity Response Dec 7, 2017 Aug 1, 2022
3332 272: Activation/Proliferation, T-cells 2256: Activation of gluten- and TG2-reactive B cells Aug 13, 2024 Aug 13, 2024 None
3334 272: Activation/Proliferation, T-cells 1931: Disruption of the intestinal barrier Aug 13, 2024 Aug 13, 2024 None
3337 272: Activation/Proliferation, T-cells 2252: Formation of HLA-DQ2/8-gluten complexes Aug 13, 2024 Aug 13, 2024 None
1652 1469: TGFbeta pathway activation 1456: Differentiation of fibroblasts Aug 16, 2017 Aug 16, 2017
1653 1469: TGFbeta pathway activation 1457: EMT Aug 16, 2017 Aug 16, 2017
1832 1576: Activation, Tissue resident cells (Kuppfer cells) 1579: Increase, proinflammatory mediators (TNFalpha) Jan 7, 2019 Jan 7, 2019
1370 1283: Activation, TGF-beta pathway 1277: Reproductive failure Feb 15, 2017 Feb 15, 2017
2153 1283: Activation, TGF-beta pathway 1457: EMT Jul 9, 2020 Jul 9, 2020
1016 978: Activation, Suppression of NFAT activation and hindrance of nuclear localization 979: Interference, nuclear localization of NFAT Nov 29, 2016 Dec 3, 2016 None
1868 1606: Activation, Stellate cell 1549: Liver Injury Mar 6, 2019 Mar 6, 2019
3733 1606: Activation, Stellate cell 68: Increase, Collagen accumulation Feb 11, 2026 Feb 11, 2026 None
294 264: Activation, SREBP-1c 89: Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
1397 1301: Activation, SREBP-1 1304: Activation, FXR Apr 12, 2017 Apr 12, 2017 None
1403 1301: Activation, SREBP-1 258: Activation, SCD-1 Apr 12, 2017 Apr 12, 2017 None
482 457: Activation, SREBF1 458: Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016 None
489 457: Activation, SREBF1 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
1662 457: Activation, SREBF1 459: Increase, Liver steatosis Aug 31, 2017 Aug 31, 2017
987 924: Activation, Sp1 962: Increase, Mucin production Nov 29, 2016 Aug 11, 2021 None
896 480: Activation, SHP 878: Inhibition, SREBP1c Nov 29, 2016 Dec 3, 2016
1409 480: Activation, SHP 227: Activation, PPARĪ± Apr 12, 2017 Apr 12, 2017 None
1412 480: Activation, SHP 1307: Inhibition, LXR Apr 12, 2017 Apr 12, 2017 None