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Showing 351 to 375 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3528	111: Agonism, Estrogen receptor	1187: Increased, ER binding to DNA (classical pathway)	Apr 28, 2025	Apr 28, 2025	1 AOP 200: Estrogen receptor activation leading to breast cancer
3529	111: Agonism, Estrogen receptor	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	Apr 28, 2025	Apr 28, 2025	1 AOP 200: Estrogen receptor activation leading to breast cancer
3530	111: Agonism, Estrogen receptor	1191: Increased, Non-genomic signaling	Apr 28, 2025	Apr 28, 2025	1 AOP 200: Estrogen receptor activation leading to breast cancer
3531	111: Agonism, Estrogen receptor	1242: Increased, Second Messenger Production	Apr 28, 2025	Apr 28, 2025	1 AOP 200: Estrogen receptor activation leading to breast cancer
3560	111: Agonism, Estrogen receptor	1066: Promotion, SIX1 positive progenitor cells in endometrium	Aug 5, 2025	Aug 5, 2025	None
3561	111: Agonism, Estrogen receptor	2329: SIX1 gene expression, increased	Aug 5, 2025	Sep 12, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
3109	2201: RAR agonism	2202: Altered expression of cell cycle genes	Jan 14, 2024	Apr 18, 2024	2 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
3113	2201: RAR agonism	2203: Decreased proliferation of cortical NPCs	Jan 14, 2024	Feb 14, 2024	2 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
3114	2201: RAR agonism	341: Impairment, Learning and memory	Jan 14, 2024	Jan 14, 2024	1 AOP 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
3128	2201: RAR agonism	2211: Microcephalus	Feb 2, 2024	Feb 2, 2024	None
3144	2201: RAR agonism	1978: Microcephaly	Mar 13, 2024	Mar 13, 2024	1 AOP 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
1838	1586: Airway epithelial injury	149: Increase, Inflammation	Jan 30, 2019	Jan 30, 2019	1 AOP 280: α-diketone-induced bronchiolitis obliterans
2681	2013: Airway remodeling	2008: Chronic obstructive pulmonary disease	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2441	1907: ASL Height, Decreased	1908: CBF, Decreased	Jul 19, 2021	Sep 28, 2021	1 AOP 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
2444	1907: ASL Height, Decreased	1910: Mucus Viscosity, Increased	Jul 19, 2021	Aug 2, 2021	None
23	97: Alkylation, DNA	336: Increase, Heritable mutations in offspring	Nov 29, 2016	Nov 29, 2016	1 AOP 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
24	97: Alkylation, DNA	155: Inadequate DNA repair	Nov 29, 2016	Dec 10, 2019	3 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1 322: Alkylation of DNA leading to reduced sperm count
25	97: Alkylation, DNA	185: Increase, Mutations	Nov 29, 2016	Nov 29, 2016	2 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1
901	97: Alkylation, DNA	885: Increase, Cancer	Nov 29, 2016	Dec 3, 2016	1 AOP 139: Alkylation of DNA leading to cancer 1
269	244: Alkylation, Protein	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	1 AOP 38: Protein Alkylation leading to Liver Fibrosis
271	244: Alkylation, Protein	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
3135	244: Alkylation, Protein	177: Increase, Mitochondrial dysfunction	Feb 28, 2024	Feb 28, 2024	1 AOP 258: Renal protein alkylation leading to kidney toxicity
3094	1060: Alteration, lipid metabolism	1513: General Apoptosis	Oct 18, 2023	Oct 19, 2023	1 AOP 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
338	310: Alteration, Wnt pathway	240: Feminisation or incomplete development, Primary and accessory male sex organs	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
997	854: Alterations, Cellular proliferation / hyperplasia	856: Formation, Hepatocellular and Bile duct tumors	Nov 29, 2016	Dec 2, 2016	1 AOP 41: Sustained AhR Activation leading to Rodent Liver Tumours

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