| 942 |
913: Activation, Epidermal Growth Factor Receptor |
919: Occurrence, Transdifferentiation of ciliated epithelial cells |
Nov 29, 2016 |
Nov 29, 2016 |
None
|
| 946 |
913: Activation, Epidermal Growth Factor Receptor |
924: Activation, Sp1 |
Nov 29, 2016 |
Dec 3, 2016 |
None
|
| 1103 |
1065: Activation, ERα |
1066: Promotion, SIX1 positive progenitor cells in endometrium |
Nov 29, 2016 |
Dec 3, 2016 |
None
|
| 2665 |
1065: Activation, ERα |
1985: Increased Kisspeptin levels in AVPV |
Jun 6, 2022 |
Feb 12, 2026 |
2 AOPs
|
| 2666 |
1065: Activation, ERα |
1986: Decreased, Gonadotropins |
Jun 6, 2022 |
Aug 15, 2022 |
1 AOP
|
| 2730 |
1065: Activation, ERα |
1991: Impaired, Reproduction |
Aug 15, 2022 |
Aug 15, 2022 |
1 AOP
|
| 2969 |
1065: Activation, ERα |
2152: Epigenetic modification process |
Jul 27, 2023 |
Apr 28, 2025 |
1 AOP
|
| 3646 |
1065: Activation, ERα |
968: Decreased, release of kisspeptin from AVPV neurons |
Oct 2, 2025 |
Jan 28, 2026 |
1 AOP
|
| 133 |
116: Activation, FAS |
89: Synthesis, De Novo Fatty Acid (FA) |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 1422 |
116: Activation, FAS |
1306: Increase, De novo lipogenesis |
Apr 13, 2017 |
Apr 13, 2017 |
None
|
| 1381 |
1293: Activation, FOXO |
1294: Inhibition, Wnt pathway |
Feb 15, 2017 |
Feb 15, 2017 |
1 AOP
|
| 3590 |
1293: Activation, FOXO |
2347: Increase, Lipid degradation |
Aug 16, 2025 |
Aug 16, 2025 |
1 AOP
|
| 1407 |
1304: Activation, FXR |
480: Activation, SHP |
Apr 12, 2017 |
Apr 12, 2017 |
None
|
| 1408 |
1304: Activation, FXR |
227: Activation, PPARα |
Apr 12, 2017 |
Apr 12, 2017 |
None
|
| 752 |
760: Activation, Glutamate-gated chloride channel |
761: Increased, Chloride conductance |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 1057 |
1018: Activation, Glutamate-gated chloride channels |
761: Increased, Chloride conductance |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 3084 |
1018: Activation, Glutamate-gated chloride channels |
388: Overactivation, NMDARs |
Oct 17, 2023 |
Oct 17, 2023 |
1 AOP
|
| 3085 |
1018: Activation, Glutamate-gated chloride channels |
2195: Increase, CNS Neural cell death |
Oct 17, 2023 |
Oct 17, 2023 |
1 AOP
|
| 1204 |
1157: Activation, Hepatic nuclear receptor(s) |
1158: Increased, Hepatic thyroid hormone uptake/transport |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 1205 |
1157: Activation, Hepatic nuclear receptor(s) |
295: Induction, Upregulation of glucuronyltransferase activity |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 1365 |
1280: Activation, HIF-1 |
1262: Apoptosis |
Feb 15, 2017 |
Feb 15, 2017 |
1 AOP
|
| 2985 |
2162: Activation, HIF1α |
2163: Activation Sema6A |
Aug 20, 2023 |
Aug 20, 2023 |
1 AOP
|
| 1411 |
1303: Activation, HSD17B4 |
451: Inhibition, Mitochondrial fatty acid beta-oxidation |
Apr 12, 2017 |
Apr 12, 2017 |
None
|
| 1415 |
1303: Activation, HSD17B4 |
1312: Increase, Fatty acid β-oxidation |
Apr 13, 2017 |
Apr 13, 2017 |
None
|
| 1699 |
151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways |
398: Activation, Dendritic Cells |
Dec 7, 2017 |
Dec 3, 2020 |
None
|