Prototypical Stressors

Showing 51 to 75 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

228	3-aminopropanal		144: Endocytic lysosomal uptake leading to liver fibrosis
866	3-Methylcholanthrene	3-Methylcholanthrene, CAS-RN: 56-49-5, DTXSID0020862	644: Bulky DNA adducts leading to chromosomal aberrations and mutations
278	3,3		None
277	3,3'		None
835	3,3',5,5'-Tetrabromobisphenol A	3,3',5,5'-Tetrabromobisphenol A, CAS-RN: 79-94-7, DTXSID1026081	565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha
758	3,3′,5,5′ tetrabromobisphenol A		2 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition
321	3,5-Dichlorophenol	3,5-Dichlorophenol, CAS-RN: 591-35-5, DTXSID2025006	2 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
466	4-biphenyl carboxylic acid		297: Inhibition of retinaldehyde dehydrogenase leads to population decline
832	4-bromo-2-(methylamino)-benzimidazole		562: HCN Channel Inhibition leading to Arrhythmias
728	4-diethylaminobenzaldehyde (DEAB)		436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
363	4-Hydroxy Nonenal		None
583	4-Hydroxytamoxifen	4-Hydroxytamoxifen, CAS-RN: 68392-35-8, DTXSID3037094	None
515	4-Nitroquinoline 1-oxide		296: Oxidative DNA damage leading to chromosomal aberrations and mutations
77	4-Nonylphenol	4-Nonylphenol, CAS-RN: 104-40-5, DTXSID5033836	None
78	4-propoxyphenol		None
220	5-(N,N-hexamethylene) amiloride (HMA)		None
442	5-Azacytidine	5-Azacytidine, CAS-RN: 320-67-2, DTXSID9020116	8 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
865	5-Methylchrysene	5-Methylchrysene, CAS-RN: 3697-24-3, DTXSID6063143	644: Bulky DNA adducts leading to chromosomal aberrations and mutations
126	518-2-5		None
267	5alpha-Dihydrotestosterone	5alpha-Dihydrotestosterone, CAS-RN: 521-18-6, DTXSID9022364	376: Androgen receptor agonism leading to male-biased sex ratio
836	7,12-Dimethylbenz(a)anthracene	7,12-Dimethylbenz(a)anthracene, CAS-RN: 57-97-6, DTXSID1020510	563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
730	a		None
544	Abamectin	Abamectin, CAS-RN: 71751-41-2, DTXSID8023892	None
868	Acenaphthene	Acenaphthene, CAS-RN: 83-32-9, DTXSID3021774	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
869	Acenaphthylene	Acenaphthylene, CAS-RN: 208-96-8, DTXSID3023845	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders