Prototypical Stressors

Showing 51 to 75 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

548	Triphenyl phosphate	Triphenyl phosphate, CAS-RN: 115-86-6, DTXSID1021952	2 AOPs 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
54	Trimethyltin chloride	Trimethyltin chloride, CAS-RN: 1066-45-1, DTXSID6042496	None
603	Triclosan	Triclosan, CAS-RN: 3380-34-5, DTXSID5032498	2 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
265	Triclopyr	Triclopyr, CAS-RN: 55335-06-3, DTXSID0032497	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
342	Trichostatin A	Trichostatin A, CAS-RN: 58880-19-6, DTXSID6037063	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 274: Histone deacetylase inhibition leads to impeded craniofacial development
209	trichloroacetic acid	Trichloroacetic acid, CAS-RN: 76-03-9, DTXSID1021378	None
304	Tributyltin	Tributyltin, CAS-RN: 688-73-3, DTXSID0040709	2 AOPs 72: Epigenetic modification of PPARG leading to adipogenesis 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
688	Tri-allate	Tri-allate, CAS-RN: 2303-17-5, DTXSID5024344	None
106	Tralomethrin	Tralomethrin, CAS-RN: 66841-25-6, DTXSID0024343	None
459	Topoisomerase inhibitors		None
93	Topiramate	Topiramate, CAS-RN: 97240-79-4, DTXSID8023688	None
554	too many stressors to list		None
747	Toluene diisocyanate	Toluene diisocyanate, CAS-RN: 26471-62-5, DTXSID0024341	39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
590	Tofacitinib (CP690,550)		None
329	Tobramycin	Tobramycin, CAS-RN: 32986-56-4, DTXSID8023680	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
357	Titanium oxide (TiO)	Titanium oxide (TiO), CAS-RN: 12137-20-1, DTXSID7065253	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
749	Titanium dioxide nanoparticles		2 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 451: Interaction with lung resident cell membrane components leads to lung cancer
839	Tissue transglutaminase 2 (TG2) enzyme activity		524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
288	Tioconazole	Tioconazole, CAS-RN: 65899-73-2, DTXSID3046619	None
761	Tian Ma (Tall Gastrodia Tuber)		2 AOPs 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function
309	Thiram	Bis(dimethylaminothiocarbonyl) disulfide, CAS-RN: 137-26-8, DTXSID5021332	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
53	Thiouracil	Thiouracil, CAS-RN: 141-90-2, DTXSID4021347	None
343	thiomersal		None
68	Thiocyanate	Thiocyanate, CAS-RN: 302-04-5, DTXSID8047763	54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
63	Thioacetamide	Thioacetamide, CAS-RN: 62-55-5, DTXSID9021340	38: Protein Alkylation leading to Liver Fibrosis