Prototypical Stressors

Showing 101 to 125 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

383	Amlodipine	Amlodipine, CAS-RN: 88150-42-9, DTXSID7022596	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
666	Ammonia	Ammonia, CAS-RN: 7664-41-7, DTXSID0023872	None
417	Amphomycin		None
778	amyloid beta		475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
143	Androstenedione		None
490	anti-IL-1b antibody (Canakinumab)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
518	anti-IL-1b antibody (Gevokizumab)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
395	Antimycin A	Antimycin A, CAS-RN: 1397-94-0, DTXSID9032325	3 AOPs 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits
404	Apicidin	Apicidin, CAS-RN: 183506-66-3, DTXSID40274182	274: Histone deacetylase inhibition leads to impeded craniofacial development
284	Aristolochic acid	Aristolochic acid, CAS-RN: 313-67-7, DTXSID0040969	397: Bulky DNA adducts leading to mutations
635	Arsenic	Arsenic, CAS-RN: 7440-38-2, DTXSID4023886	5 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 550: Increased LMNA gene mutation leading to heart failure 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
430	Arsenite	Arsenite, CAS-RN: 15502-74-6, DTXSID0074007	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
229	artesunate	Artesunate, CAS-RN: 88495-63-0, DTXSID3042681	144: Endocytic lysosomal uptake leading to liver fibrosis
81	Aryltrifluoroborates		54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
671	Asbestos fibers	Asbestos fibers, CAS-RN: NOCAS, DTXSID0030740	409: Frustrated phagocytosis leads to malignant mesothelioma
534	Ascomycin		154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
156	Aspartame	Aspartame, CAS-RN: 22839-47-0, DTXSID0020107	None
432	Aspirin	Aspirin, CAS-RN: 50-78-2, DTXSID5020108	None
701	Astemizole	Astemizole, CAS-RN: 68844-77-9, DTXSID9020110	None
549	Atorvastatin	Atorvastatin, CAS-RN: 134523-00-5, DTXSID8029868	None
177	atrazine	Atrazine, CAS-RN: 1912-24-9, DTXSID9020112	5 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
425	Aurovertin		None
536	Azathioprine	Azathioprine, CAS-RN: 446-86-6, DTXSID4020119	None
266	B2,4,2',		None
625	bacteria		374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis