| 536 |
Estrogen receptor agonism leading to reduced survival and population growth due to renal failure |
Camille Baettig |
BY-SA |
111: Agonism, Estrogen receptor
|
None
|
|
|
| 537 |
Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver |
Jason M. O'Brien |
BY-SA |
111: Agonism, Estrogen receptor
|
78: Reduction, Cumulative fecundity and spawning
|
|
|
| 538 |
Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways |
Yanhong Wei |
All rights reserved |
None
|
2161: Increase, Vascular disrupting effects
|
|
|
| 539 |
Decreased Sodium/Potassium ATPase activity leads to Heart failure |
John Frisch |
BY-SA |
1562: Decreased Na/K ATPase activity
|
1535: Heart failure
|
|
|
| 540 |
Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production |
Kevin Brix |
All rights reserved |
1115: Increase, Reactive oxygen species
|
360: Decrease, Population growth rate
|
|
|
| 541 |
Excessive ROS generation leading to increased incidence of vascular calcification by VSMC phenotype switching |
Ruiyang Ding |
All rights reserved |
None
|
None
|
|
|
| 543 |
Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration |
Brooke Bowe |
All rights reserved |
2262: Neuropathy target esterase, inhibited
|
2267: Delayed neuropathy, increased
|
|
|
| 544 |
Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation |
Brooke Bowe |
All rights reserved |
2262: Neuropathy target esterase, inhibited
|
2267: Delayed neuropathy, increased
|
|
|
| 545 |
Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis |
John Frisch |
BY-SA |
239: Activation, Pregnane-X receptor, NR1l2
|
2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
|
|
|
| 546 |
Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms |
Sylvie Bortoli |
All rights reserved |
2118: Succinate dehydrogenase, inhibited
|
885: Increase, Cancer
|
|
|
| 547 |
Androgen receptor agonism leading to long anogenital distance in female offspring |
Johanna Zilliacus |
All rights reserved |
25: Agonism, Androgen receptor
|
2365: Anogenital distance (AGD), increased
|
|
|
| 548 |
Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression |
John Frisch |
BY-SA |
239: Activation, Pregnane-X receptor, NR1l2
|
2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
|
|
|
| 549 |
Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish |
Hongling Liu |
BY-SA |
36: Inhibition, Aromatase
|
3 AOs
|
|
|
| 550 |
Increased LMNA gene mutation leading to heart failure |
Young Jun Kim |
BY-SA |
2278: Increased LMNA Mutation
|
1535: Heart failure
|
|
|
| 551 |
Increased Muscarinic M2 Receptor leading to Arrhythmia |
Young Jun Kim |
Open for adoption |
1602: Increased Muscarinic Acetylcholine Receptors
|
1106: Occurrence, cardiac arrhythmia
|
|
|
| 552 |
Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) |
Young Jun Kim |
All rights reserved |
1529: Blockade, L-Type Calcium Channels
|
1535: Heart failure
|
|
|
| 553 |
Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure |
Young Jun Kim |
All rights reserved |
584: Inhibition, sodium channel
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1535: Heart failure
|
|
|
| 554 |
β-adrenergic receptor agonists leading to arrhythmias. |
Young Jun Kim |
All rights reserved |
1038: Activation, beta-2 adrenergic receptor
|
1106: Occurrence, cardiac arrhythmia
|
|
|
| 555 |
Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure |
Young Jun Kim |
All rights reserved |
593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
|
1535: Heart failure
|
|
|
| 556 |
Decreased Na/K ATPase activity leading to heart failure |
Young Jun Kim |
All rights reserved |
1562: Decreased Na/K ATPase activity
|
1535: Heart failure
|
|
|
| 557 |
β2-Receptor agonist leading to Cardiomyopathy |
Young Jun Kim |
All rights reserved |
1039: Increased activity, beta-2 adrenergic receptor
|
2157: Abnormal Cardiac Structure and Function
|
|
|
| 558 |
Phosphodiesterase inhibition leading to heart failure |
Young Jun Kim |
All rights reserved |
2288: Phosphodiesterase inhibition
|
1535: Heart failure
|
|
|
| 559 |
Inhibition of acetylcholinesterase (AChE) leading to arrhythmias |
Young Jun Kim |
All rights reserved |
12: Acetylcholinesterase (AchE) Inhibition
|
1106: Occurrence, cardiac arrhythmia
|
|
|
| 560 |
Inhibition of Funny current (If) leading to Arrhythmias |
Young Jun Kim |
Open for adoption |
2290: Inhibition of Funny current (If)
|
1106: Occurrence, cardiac arrhythmia
|
|
|
| 561 |
Aromatase induction leading to estrogen receptor alpha activation via increased estradiol |
Martina Panzarea |
All rights reserved |
2293: Aromatase, induction
|
1065: Activation, estrogen receptor alpha
|
|
|