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All Key Events

Showing 226 to 250 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

466	Up Regulation, LDLR (low density lipoprotein receptor) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	57: AhR activation leading to hepatic steatosis
467	Increased, LDL uptake Short Name Increased, LDL uptake	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 57: AhR activation leading to hepatic steatosis 462: Activation of reactive oxygen species leading the atherosclerosis
468	Inhibition, PPAR alpha Short Name Inhibition, PPAR alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
470	Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
471	Inhibition, FoxA2 Short Name Inhibition, FoxA2	1	Molecular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
472	Down Regulation, CPT1A Short Name Down Regulation, CPT1A	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
474	Down Regulation, HMGCS2 Short Name Down Regulation, HMGCS2	1	Molecular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
477	Decreased, Ketogenesis Short Name Decreased, Ketogenesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
478	Activation, NRF2 Short Name Activation, NRF2	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
479	Activation, NR1H4 Short Name Activation, NR1H4	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
480	Activation, SHP Short Name Activation, SHP	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
482	Decreased, DHB4/HSD17B4 Short Name Decreased, DHB4/HSD17B4	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
483	Activation, LXR alpha Short Name Activation, LXR alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
484	Activation, AKT2 Short Name Activation, AKT2	1	Molecular	Nov 29, 2016	Sep 16, 2017	62: AKT2 activation leading to hepatic steatosis
486	systemic inflammation leading to hepatic steatosis Short Name inflammation	1	Organ	Nov 29, 2016	Feb 24, 2017	62: AKT2 activation leading to hepatic steatosis
488	Decrease, Ovulation Short Name Decrease, Ovulation	1	Organ	Nov 29, 2016	Sep 16, 2017	63: Cyclooxygenase inhibition leading to reproductive dysfunction
491	Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
493	Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
494	Glucocorticoid Receptor Agonist, Activation Short Name GR Agonist, Activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
495	Repressed expression of steroidogenic enzymes Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 595: Emerging OPFRS reproductive outcome pathway
496	Increased apoptosis, decreased fetal/adult Leydig Cells Short Name Decreased Leydig Cells	1	Cellular	Nov 29, 2016	May 17, 2023	2 AOPs 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
505	Decreased sperm quantity / quality in the adult, Decreased fertility Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	3 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
520	Decreased sperm quantity or quality in the adult, Decreased fertility Short Name	4	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 595: Emerging OPFRS reproductive outcome pathway
525	Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
526	Inhibition, Inhibition of Dopamine-beta-hydroxylase Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity