AOP-Wiki

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All Key Events

Showing 1101 to 1125 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1288	Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene Short Name	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP 594: Micro plastic effect on reproduction
1287	Glutathione synthesis Short Name Glutathione synthesis	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1286	Down Regulation, GSS and GSTs gene Short Name Down Regulation, GSS and GSTs gene	2	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1285	Up Regulation, Unsaturated fatty acid Short Name Up Regulation, Unsaturated fatty acid	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1284	Up Regulation, SREBF2 Short Name Up Regulation, SREBF2	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1283	Activation, TGF-beta pathway Short Name Activation, TGF-beta pathway	1	Cellular	Feb 15, 2017	Sep 16, 2017	3 AOPs 208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
1282	Activation, JAK/STAT pathway Short Name Activation, JAK/STAT pathway	2	Cellular	Feb 15, 2017	Sep 16, 2017	208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
1281	Increased, DNA Damage-Repair Short Name Increased, DNA Damage-Repair	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
1280	Activation, HIF-1 Short Name Activation, HIF-1	1	Cellular	Feb 15, 2017	Sep 16, 2017	207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1279	Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK Short Name	2	Cellular	Feb 15, 2017	Sep 16, 2017	207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1277	Reproductive failure Short Name Reproductive failure	1	Individual	Feb 15, 2017	Feb 15, 2017	4 AOPs 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 594: Micro plastic effect on reproduction
1276	Lung fibrosis Short Name Lung fibrosis	0	Organ	Feb 15, 2017	Dec 26, 2017	5 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway
1275	Collagen Deposition Short Name Collagen Deposition	0	Tissue	Feb 15, 2017	Feb 15, 2017	206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
1274	Production of α-smooth muscle actin Short Name Production of α-smooth muscle actin	0	Cellular	Feb 15, 2017	Feb 15, 2017	None
1273	Expression of Collagen Short Name Expression of Collagen	0	Cellular	Feb 15, 2017	Feb 15, 2017	None
1272	Increase, Myofibroblast expansion Short Name Increase, Myofibroblast expansion	0	Cellular	Feb 15, 2017	Feb 10, 2026	None
1271	Increase, Transforming growth factor-beta signaling Short Name Activation of TGF-β signaling	0	Molecular	Feb 15, 2017	Feb 11, 2026	7 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1270	Inactivation of PPARγ Short Name Inactivation of PPARγ	0	Molecular	Feb 15, 2017	Dec 26, 2017	2 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1269	Increase, COX-2 expression Short Name Increase, COX-2 expression	1	Molecular	Feb 9, 2017	Mar 20, 2018	21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
1268	Decrease, Excitatory postsynaptic potential Short Name	1	Tissue	Feb 9, 2017	May 24, 2018	None
1267	Decrease, Ecdysis motor program activity Short Name	1	Tissue	Feb 9, 2017	Sep 29, 2025	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1266	Decrease, Circulating crustacean cardioactive peptide Short Name Decrease, Circulating CCAP	1	Tissue	Feb 9, 2017	May 24, 2018	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1265	Decrease, Fushi tarazu factor-1 gene expression Short Name Decrease, Ftz-f1 expression	1	Molecular	Feb 9, 2017	Sep 26, 2025	4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
1264	Increase, Nuclear receptor E75b gene expression Short Name Increase, E75b expression	1	Molecular	Feb 9, 2017	May 24, 2018	4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
1263	Necrosis Short Name Necrosis	1	Tissue	Feb 7, 2017	Feb 7, 2017	2 AOPs 205: AOP from chemical insult to cell death 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis