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All Key Events

Showing 1551 to 1575 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

745	Increase, Leydig cell tumors Short Name Increase, Leydig cell tumors	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
744	Increase, Hyperplasia (Leydig cells) Short Name Increase, Hyperplasia (Leydig cells)	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
743	Decreased, Testosterone binding to androgen receptor (hypothalamus) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
741	Increase, Adenomas/carcinomas (follicular cell) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
740	Increase, Hyperplasia (follicular cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
739	Increase, Hypertrophy and proliferation (follicular cell) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
737	Decreased, Uptake of inorganic iodide Short Name Decreased, Uptake of inorganic iodide	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
736	Increase, Adenomas/carcinomas (bronchioloalveolar) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
735	Increase, Hyperplasia (terminal bronchiolar cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
734	Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
733	Increase, Necrosis (terminal bronchiolar cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
728	Increase, Aneuploid offspring Short Name Increase, Aneuploid offspring	1	Individual	Nov 29, 2016	May 27, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
726	Increased, Induction of pyruvate dehydrogenase (PDH) Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
724	Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
723	Altered, Chromosome number Short Name Altered, Chromosome number	1	Cellular	Nov 29, 2016	May 27, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
721	Disorganization, Meiotic Spindle Short Name Disorganization, Meiotic Spindle	1	Cellular	Nov 29, 2016	Apr 20, 2021	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
720	Disruption, Microtubule dynamics Short Name Disruption, Microtubule dynamics	1	Molecular	Nov 29, 2016	Nov 7, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
719	Increase, hepatocellular adenomas and carcinomas Short Name	3	Tissue	Nov 29, 2016	Dec 26, 2020	5 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
718	Binding, Tubulin Short Name Binding, Tubulin	2	Molecular	Nov 29, 2016	Apr 20, 2021	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
716	Increase, cell proliferation (hepatocytes) Short Name	2	Cellular	Nov 29, 2016	Jan 6, 2021	3 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
715	Activation, Constitutive androstane receptor Short Name	1	Molecular	Nov 29, 2016	Jun 28, 2018	107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
714	Increased, Binding of chemicals to 2u (serum) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
713	Increase, Adenomas/carcinomas (renal tubular) Short Name	3	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
710	Increase, Regenerative cell proliferation (tubular epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
709	Increase, Cytotoxicity (renal tubular cell) Short Name	1	Cellular	Nov 29, 2016	Mar 3, 2022	5 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 258: Renal protein alkylation leading to kidney toxicity 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity