AOP-Wiki

API

All Key Events

Showing 1576 to 1600 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

708	Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
699	Increased, cardiac arrthymia Short Name Increased, cardiac arrthymia	1	Organ	Nov 29, 2016	Sep 16, 2017	104: Altered ion channel activity leading impaired heart function
698	Altered, Action Potential Short Name Altered, Action Potential	1	Cellular	Nov 29, 2016	Mar 31, 2022	4 AOPs 104: Altered ion channel activity leading impaired heart function 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
697	impaired, ion channels Short Name impaired, ion channels	2	Cellular	Nov 29, 2016	Dec 3, 2016	104: Altered ion channel activity leading impaired heart function
696	Increased, Chromosome misseggregation Short Name Increased, Chromosome misseggregation	1	Cellular	Nov 29, 2016	Sep 16, 2017	103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
695	Upregulated, Spindle assembly checkpoint protein Mad2-oocyte Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
694	Reduced, Meiotic prophase I/metaphase I transition, oocyte Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
693	Increased, cyclic adenosine monophosphate Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 558: Phosphodiesterase inhibition leading to heart failure
692	Reduced, Maturation inducing steroid receptor signalling, oocyte Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
691	Reduced, Maturation inducing steroid, plasma Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
690	Reduced, Luteinizing hormone (LH), plasma Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
689	Reduced, Gonadotropin releasing hormone, hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
687	Reduced, Prostaglandin E2 concentration, hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
685	Reduced, Prostaglandins, ovary Short Name Reduced, Prostaglandins, ovary	1	Organ	Nov 29, 2016	Sep 16, 2017	63: Cyclooxygenase inhibition leading to reproductive dysfunction
682	Generation, Amplified excitatory postsynaptic potential (EPSP) Short Name	1	Cellular	Nov 29, 2016	May 18, 2018	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
681	Decreased, Prostaglandin F2alpha synthesis, ovary Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
679	Decline, Population trajectory Short Name Decline, Population trajectory	1	Population	Nov 29, 2016	Dec 3, 2016	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
678	Reduced, Pheromone release Short Name Reduced, Pheromone release	1	Individual	Nov 29, 2016	Dec 3, 2016	101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
675	Reduced, Reproductive Success Short Name Reduced, Reproductive Success	2	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
674	Reduced, Ability to attract spawning mates Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
673	Reduced, Spawning behavior Short Name Reduced, Spawning behavior	1	Individual	Nov 29, 2016	Dec 3, 2016	100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
672	Reduced, Prostaglandin F2alpha synthesis, ovary Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
671	Reduced, Prostaglandin F2alpha concentration, plasma Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
669	Reduction, Neuronal synaptic inhibition Short Name Reduction, Neuronal synaptic inhibition	1	Cellular	Nov 29, 2016	May 16, 2018	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
667	Binding at picrotoxin site, iGABAR chloride channel Short Name	3	Molecular	Nov 29, 2016	Apr 29, 2019	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain