AOP-Wiki

API

All Key Events

Showing 501 to 525 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

898	Disruption, Lysosome Short Name Disruption, Lysosome	1	Cellular	Nov 29, 2016	Aug 29, 2024	3 AOPs 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
901	Infiltration, Inflammatory cells Short Name Infiltration, Inflammatory cells	1	Tissue	Nov 29, 2016	Sep 16, 2017	462: Activation of reactive oxygen species leading the atherosclerosis
902	Inflammation, Liver Short Name Inflammation, Liver	1	Organ	Nov 29, 2016	Sep 16, 2017	2 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
907	Infiltration, Inflammatory cytokines Short Name Infiltration, Inflammatory cytokines	0		Nov 29, 2016	Nov 29, 2016	None
913	Activation, Epidermal Growth Factor Receptor Short Name	0		Nov 29, 2016	Nov 29, 2016	None
914	Decrease, Apoptosis of ciliated epithelial cells Short Name Decreased ciliated cell apoptosis	1	Cellular	Nov 29, 2016	Aug 17, 2021	None
919	Occurrence, Transdifferentiation of ciliated epithelial cells Short Name	1	Cellular	Nov 29, 2016	Aug 17, 2021	None
920	Occurrence, Metaplasia of goblet cells Short Name Goblet cell metaplasia	1	Tissue	Nov 29, 2016	Aug 23, 2021	None
921	Occurrence, Hyperplasia of goblet cells Short Name Goblet cell hyperplasia	1	Tissue	Nov 29, 2016	Sep 21, 2021	None
923	Increase, Proliferation of goblet cells Short Name Increased goblet cell proliferation	1	Cellular	Nov 29, 2016	Aug 20, 2021	None
924	Activation, Sp1 Short Name Activation, Sp1	1	Molecular	Nov 29, 2016	Aug 20, 2021	None
926	Oxidation, Glutathione (To be considered with MIE) Short Name Oxidation, Glutathione	1	Molecular	Nov 29, 2016	Nov 9, 2017	2 AOPs 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
927	KE1 : S-Glutathionylation, eNOS Short Name S-Glutathionylation, eNOS	2	Molecular	Nov 29, 2016	Nov 20, 2017	149: Peptide Oxidation Leading to Hypertension
932	KE4 : Uncoupling, eNOS Short Name Uncoupling, eNOS	1	Cellular	Nov 29, 2016	Nov 9, 2017	2 AOPs 149: Peptide Oxidation Leading to Hypertension 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
933	KE6 : Depletion, Nitric Oxide Short Name Depletion, Nitric Oxide	1	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
934	KE3 : Decrease, Tetrahydrobiopterin Short Name Decrease, Tetrahydrobiopterin	1	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
935	KE2 : Decrease, GTPCH-1 Short Name Decrease, GTPCH-1	1	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
937	KE7 : Impaired, Vasodilation Short Name Impaired, Vasodilation	1	Organ	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
941	Activation, EGFR Short Name Activation, EGFR	2	Molecular	Nov 29, 2016	Mar 8, 2023	148: EGFR Activation Leading to Decreased Lung Function
943	Hypersecretion, Mucus Short Name Hypersecretion, Mucus	0	Organ	Nov 29, 2016	Nov 29, 2016	None
944	dimerization, AHR/ARNT Short Name dimerization, AHR/ARNT	2	Molecular	Nov 29, 2016	May 31, 2025	7 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
945	reduced dimerization, ARNT/HIF1-alpha Short Name reduced dimerization, ARNT/HIF1-alpha	2	Molecular	Nov 29, 2016	Mar 23, 2018	2 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 151: AhR activation leading to preeclampsia
947	Increase, Early Life Stage Mortality Short Name Increase, Early Life Stage Mortality	2	Individual	Nov 29, 2016	Mar 22, 2018	7 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
948	reduced production, VEGF Short Name reduced production, VEGF	2	Cellular	Nov 29, 2016	Mar 28, 2018	3 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 151: AhR activation leading to preeclampsia 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
951	KE8 : Increase, Vascular Resistance Short Name Increase, Vascular Resistance	1	Organ	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension