AOP-Wiki

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All Key Events

Showing 1351 to 1375 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1843	Multi Organ Failure involving Acute Respiratory Distress Syndrome Short Name ARDS and MODS	0	Individual	Mar 19, 2021	Nov 19, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1844	systemic inflammatory response syndrome Short Name SIRS	0	Individual	Mar 19, 2021	Mar 19, 2021	2 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
1845	Coagulation Short Name Coagulation	1	Organ	Mar 25, 2021	Aug 30, 2023	379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
1846	Thrombosis and Disseminated Intravascular Coagulation Short Name Thrombosis and DIC	3	Individual	Mar 25, 2021	Nov 25, 2022	3 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1847	Increased SARS-CoV-2 production Short Name SARS-CoV-2 production	5	Cellular	Mar 25, 2021	Jun 14, 2022	8 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1848	Toll Like Receptor (TLR) Dysregulation Short Name TLR Activation/Dysregulation	0	Molecular	Mar 26, 2021	Nov 23, 2021	3 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 378: Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
1849	Impaired gustatory nerve Short Name Impaired gustatory nerve	0	Tissue	Mar 28, 2021	Apr 7, 2021	381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1850	dysgeusia Short Name taste impairment	0	Organ	Mar 28, 2021	Apr 26, 2021	381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1851	Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) Short Name	0	Molecular	Mar 30, 2021	Mar 30, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
1852	Increased Ang II type 1 receptor (AT1R) Short Name Increased Ang II type 1 receptor (AT1R)	0	Tissue	Mar 30, 2021	Mar 30, 2021	2 AOPs 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
1853	Hyperactivation of ACE/Ang-II/AT1R axis Short Name Hyperactivation of ACE/Ang-II/AT1R axis	0	Molecular	Mar 31, 2021	Mar 31, 2021	2 AOPs 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease 427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1854	Dysregulation, ACE2 expression and activity Short Name ACE2 dysregulation	4	Molecular	Mar 31, 2021	Feb 18, 2023	3 AOPs 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis 319: Binding to ACE2 leading to lung fibrosis
1855	Increased Sodium-sensitive hypertension Short Name Increased Sodium-sensitive hypertension	0	Tissue	Apr 7, 2021	Apr 7, 2021	384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
1856	Imbalanced salty and sweet taste responses Short Name Sodium inhibition, Sweet enhancement	0	Tissue	Apr 7, 2021	Apr 7, 2021	381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1857	Platelet-neutrophil interactions, Increased Short Name	0	Cellular	Apr 8, 2021	Apr 8, 2021	2 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 412: Endothelial cell dysfunction leading to thromboinflammation
1858	Increased viral transcription and replication Short Name	0	Cellular	Apr 9, 2021	Apr 9, 2021	None
1859	Excitation of intracellular water Short Name Excitation of intracellular water	0	Molecular	Apr 11, 2021	Apr 11, 2021	None
1860	Increase, Excitation of intracellular water Short Name Excitation of intracellular water	0	Molecular	Apr 11, 2021	Apr 11, 2021	None
1861	Increase, D1 protein deactivation Short Name D1 protein deactivation	0	Cellular	Apr 11, 2021	Apr 11, 2021	386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
1862	Decrease, Photosystem II efficiency Short Name Decrease, Photosystem II efficiency	0	Cellular	Apr 11, 2021	Jan 16, 2026	3 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
1863	Decrease, Reproduction Short Name Decrease, Reproduction	0	Individual	Apr 11, 2021	Apr 11, 2021	9 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 435: Deposition of ionising energy leads to population decline via pollen abnormal 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 595: Emerging OPFRS reproductive outcome pathway
1864	Increase, Programmed cell death Short Name Increase, Programmed cell death	0	Cellular	Apr 11, 2021	Apr 12, 2021	388: Deposition of ionising energy leading to population decline via programmed cell death
1865	Increase, Oxygen-evolving complex damage Short Name Increase, OEC damage	0	Molecular	Apr 11, 2021	Apr 11, 2021	389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1866	Fibrinolysis, decreased Short Name Hypofibrinolysis	2	Molecular	Apr 20, 2021	Oct 19, 2021	392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
1867	Bradykinin system, hyperactivated Short Name Bradykinin, activated	3	Molecular	Apr 20, 2021	Jan 24, 2022	392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation