AOP-Wiki

API

All KERs

Showing 376 to 400 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2911	854: Alterations, Cellular proliferation / hyperplasia	2136: prostatic intraepithelial neoplasia	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
2844	2089: Altered Bone Cell Homeostasis	2090: Bone Remodeling	Jan 25, 2023	Aug 9, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
3527	2089: Altered Bone Cell Homeostasis	1761: Inhibition, Fin regeneration	Apr 18, 2025	Apr 18, 2025	1 AOP 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
3112	2204: Altered brain morphology	341: Impairment, Learning and memory	Jan 14, 2024	Jan 14, 2024	1 AOP 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
3435	2292: Altered Cardiac Electrical Conduction	1106: Occurrence, cardiac arrhythmia	Nov 22, 2024	Nov 22, 2024	2 AOPs 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
3320	2245: Altered cell differentiation signaling	2089: Altered Bone Cell Homeostasis	Jul 24, 2024	Aug 23, 2024	2 AOPs 482: Deposition of energy leading to occurrence of bone loss 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
3110	2202: Altered expression of cell cycle genes	2203: Decreased proliferation of cortical NPCs	Jan 14, 2024	Jan 14, 2024	2 AOPs 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
1269	1214: Altered expression of hepatic CAR-dependent genes	716: Increase, cell proliferation (hepatocytes)	Nov 29, 2016	Dec 21, 2018	1 AOP 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
16	17: Altered expression of AHR/ARNT pathway-dependent genes	317: Altered, Cardiovascular development/function	Nov 29, 2016	Dec 3, 2016	None
17	17: Altered expression of AHR/ARNT pathway-dependent genes	80: Up Regulation, CYP1A1	Nov 29, 2016	Dec 3, 2016	None
2641	1917: Altered expression of NRF2 pathway-dependent genes	1815: Increase, ER stress	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3271	1917: Altered expression of NRF2 pathway-dependent genes	1392: Increase, Oxidative Stress	Jul 4, 2024	Jul 4, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3194	2221: LXR activity, altered	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3243	2005: neurotrasmission in development	757: Hippocampal anatomy, Altered	Jun 3, 2024	Jul 31, 2024	1 AOP 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
2773	2066: Altered Signaling	2067: Altered, Nitric Oxide Levels	Sep 28, 2022	Mar 21, 2023	None
2775	2066: Altered Signaling	2068: Increase, Endothelial Dysfunction	Sep 28, 2022	Mar 21, 2023	None
2840	2066: Altered Signaling	2098: Abnormal Neural Remodeling	Jan 25, 2023	Mar 21, 2023	None
2843	2066: Altered Signaling	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Mar 22, 2023	None
3400	2066: Altered Signaling	1924: Increased，Cardiac fibrosis	Nov 20, 2024	Nov 20, 2024	1 AOP 550: Increased LMNA gene mutation leading to heart failure
3317	2244: Altered Stress Response Signaling	2067: Altered, Nitric Oxide Levels	Jul 24, 2024	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
3318	2244: Altered Stress Response Signaling	2068: Increase, Endothelial Dysfunction	Jul 24, 2024	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
3321	2244: Altered Stress Response Signaling	2098: Abnormal Neural Remodeling	Jul 24, 2024	Jul 25, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
702	698: Altered, Action Potential	699: Increased, cardiac arrthymia	Nov 29, 2016	Dec 3, 2016	1 AOP 104: Altered ion channel activity leading impaired heart function
3407	698: Altered, Action Potential	1962: Prolongation of QT interval	Nov 20, 2024	Nov 20, 2024	1 AOP 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
3415	698: Altered, Action Potential	1532: Decrease, Cardiac contractility	Nov 21, 2024	Nov 21, 2024	1 AOP 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure

Key Event Relationships (KERs)

All KERs