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Showing 626 to 650 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3625	1696: Decrease of egg production and cummulative fecundity	1863: Decrease, Reproduction	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
871	851: GABAergic interneurons, Decreased	385: Synaptogenesis, Decreased	Nov 29, 2016	Jan 19, 2018	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
359	386: Neuronal network function, Decreased	341: Impairment, Learning and memory	Nov 29, 2016	Jul 15, 2022	6 AOPs 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
2411	386: Neuronal network function, Decreased	402: Cognitive function, decreased	Jun 24, 2021	Aug 27, 2021	1 AOP 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
2501	386: Neuronal network function, Decreased	1941: Memory Loss	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2953	386: Neuronal network function, Decreased	2150: Neurological disorder	Jun 21, 2023	Jun 21, 2023	1 AOP 501: Excessive iron accumulation leading to neurological disorders
3123	386: Neuronal network function, Decreased	2209: autism-like behavior	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
3666	386: Neuronal network function, Decreased	2108: Altered, white brain matter	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3768	386: Neuronal network function, Decreased	2416: ALS	Apr 2, 2026	Apr 2, 2026	1 AOP 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
358	385: Synaptogenesis, Decreased	386: Neuronal network function, Decreased	Nov 29, 2016	May 25, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
656	385: Synaptogenesis, Decreased	188: Neuroinflammation	Nov 29, 2016	Dec 3, 2016	None
3656	385: Synaptogenesis, Decreased	2377: neural network formation	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
443	425: Thyroidal Iodide, Decreased	281: T4 in serum, Decreased	Nov 29, 2016	Nov 29, 2016	None
872	425: Thyroidal Iodide, Decreased	277: TH synthesis, Decreased	Nov 29, 2016	Jun 4, 2018	4 AOPs 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
3720	2409: Decrease, 11β-HSD2 activity	2119: Increase, Insulin resistance	Feb 10, 2026	Feb 10, 2026	None
3731	2409: Decrease, 11β-HSD2 activity	450: Decrease, VLDL export capacity	Feb 11, 2026	Feb 11, 2026	None
3734	2409: Decrease, 11β-HSD2 activity	1306: Increase, De novo lipogenesis	Feb 11, 2026	Feb 11, 2026	None
2752	2058: Decrease, 20-hydroxyecdysone	2059: Decrease, knickkopf gene	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
1010	993: Decrease, Abdominal muscle contraction	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
2267	1834: Decrease, ACAD	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	Jan 15, 2021	Jan 15, 2021	1 AOP 318: Glucocorticoid Receptor activation leading to hepatic steatosis
2096	1771: Decrease, ATP pool	350: Increase, Mortality	Apr 30, 2020	Apr 30, 2020	2 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3)
2120	1771: Decrease, ATP pool	1775: Increase, Oocyte apoptosis	May 8, 2020	May 8, 2020	None
2121	1771: Decrease, ATP pool	1607: Increase, Necrosis	May 8, 2020	May 8, 2020	None
2179	1771: Decrease, ATP pool	1810: Decrease, ATPase activity	Nov 2, 2020	Nov 2, 2020	None
2204	1771: Decrease, ATP pool	1821: Decrease, Cell proliferation	Nov 12, 2020	Dec 7, 2020	6 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation

Key Event Relationships (KERs)

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