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Showing 2676 to 2700 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3468	1262: Apoptosis	1883: Decreased, ovarian reserve	Jan 4, 2025	May 31, 2025	1 AOP 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
3693	1262: Apoptosis	2391: Reduced fertility	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3759	1262: Apoptosis	344: Increase, Liver fibrosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3760	1262: Apoptosis	1395: Liver Cancer	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3802	1262: Apoptosis	1757: Decrease, Sperm count	Jul 3, 2026	Jul 3, 2026	1 AOP 322: Alkylation of DNA leading to decreased sperm count
1194	1148: Anticoagulant rodenticide interferes with gamma-carboxyglutamate formation, Inhibition of p	1149: Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone protei	Nov 29, 2016	Dec 3, 2016	None
1986	1691: Antagonism,LH receptor	1692: Reduction, Progesterone synthesis	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1947	1656: TR Antagnoism	756: Hippocampal gene expression, Altered	Jun 8, 2019	Jun 8, 2019	1 AOP 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
1948	1656: TR Antagnoism	402: Cognitive function, decreased	Jun 8, 2019	Jun 8, 2019	1 AOP 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
3186	1656: TR Antagnoism	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3193	1656: TR Antagnoism	2107: Hypomyelination	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3655	1656: TR Antagnoism	381: BDNF, Reduced	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3660	1656: TR Antagnoism	1505: Cell cycle disruption	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3661	1656: TR Antagnoism	2105: Decreased, mbp expression in oligodendrocytes	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2720	2027: Antagonism Smoothened	2028: Decrease, GLI1/2 translocation	Jul 28, 2022	Jul 28, 2022	None
2734	2027: Antagonism Smoothened	2044: Decrease, SMO relocation	Aug 23, 2022	Apr 2, 2025	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
2894	2027: Antagonism Smoothened	2042: orofacial cleft	Apr 14, 2023	Apr 4, 2025	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
1061	638: Antagonism, Histamine Receptor (H2)	633: Decrease, histaminergic neuron excitation	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
129	112: Antagonism, Estrogen receptor	285: Reduction, Vitellogenin synthesis in liver	Nov 29, 2016	Nov 30, 2016	1 AOP 30: Estrogen receptor antagonism leading to reproductive dysfunction
2613	112: Antagonism, Estrogen receptor	1457: EMT	Mar 22, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
3120	112: Antagonism, Estrogen receptor	2207: inhibition, EKR1/2 signaling pathway	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
2123	26: Antagonism, Androgen receptor	1688: AGD, decreased	May 11, 2020	Aug 7, 2020	None
2130	26: Antagonism, Androgen receptor	1614: Decrease, AR activation	May 11, 2020	Mar 20, 2026	4 AOPs 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
2133	26: Antagonism, Androgen receptor	1786: nipple retention, increased	May 11, 2020	Mar 21, 2026	1 AOP 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
2201	26: Antagonism, Androgen receptor	286: Altered, Transcription of genes by the AR	Nov 2, 2020	Feb 2, 2021	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)

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