Key Event Relationships (KERs)

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Showing 2851 to 2875 of 3164 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1414 480: Activation, SHP 1308: Inhibition, LRH-1 Apr 12, 2017 Apr 12, 2017 None
284 258: Activation, SCD-1 89: Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
1404 258: Activation, SCD-1 1306: Increase, De novo lipogenesis Apr 12, 2017 Apr 12, 2017 None
518 245: Activation, PXR/SXR 471: Inhibition, FoxA2 Nov 29, 2016 Dec 3, 2016
526 245: Activation, PXR/SXR 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
529 245: Activation, PXR/SXR 54: Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
3798 245: Activation, PXR/SXR 2429: Instability of INSIG1 Jun 9, 2026 Jun 9, 2026 None
1478 1370: Activation, PTGS-2 1377: Decrease, leukocyte adherence Apr 17, 2017 Apr 17, 2017
1479 1370: Activation, PTGS-2 1376: Increase, angiogenesis Apr 17, 2017 Apr 17, 2017
1480 1369: Activation, PTGS-1 1375: Increase, platelet aggregation Apr 17, 2017 Apr 17, 2017
1481 1369: Activation, PTGS-1 1374: Increase, mucosal blood flow Apr 17, 2017 Apr 17, 2017
1482 1369: Activation, PTGS-1 1373: Increase, mucous Apr 17, 2017 Apr 17, 2017
1483 1369: Activation, PTGS-1 1372: Increase, bicarbonate Apr 17, 2017 Apr 17, 2017
2482 239: Activation, Pregnane-X receptor, NR1I2 295: Induction, Upregulation of glucuronyltransferase activity Sep 14, 2021 Sep 14, 2021
3100 239: Activation, Pregnane-X receptor, NR1I2 54: Up Regulation, CD36 Nov 30, 2023 Mar 27, 2024
3365 239: Activation, Pregnane-X receptor, NR1I2 2268: Decreased, INSIG1 protein activity Oct 22, 2024 Feb 10, 2025
340 380: Activation, Pre-MIE: Metabolism of AFB1 373: Formation, Pro-mutagenic DNA Adducts Nov 29, 2016 Dec 3, 2016 None
369 227: Activation, PPARα 266: Decrease, Steroidogenic acute regulatory protein (STAR) Nov 29, 2016 Dec 2, 2016
370 227: Activation, PPARα 289: Decrease, Translocator protein (TSPO) Nov 29, 2016 Dec 2, 2016
535 227: Activation, PPARα 483: Activation, LXR alpha Nov 29, 2016 Dec 3, 2016
1229 227: Activation, PPARα 1170: Increase, Phenotypic enzyme activity Nov 29, 2016 Dec 31, 2020
1233 227: Activation, PPARα 1175: Increase, Genes involved in fatty acid oxidation Nov 29, 2016 Dec 3, 2016 None
1236 227: Activation, PPARα 1174: Activation, NADPH Oxidase Nov 29, 2016 Dec 3, 2016 None
1410 227: Activation, PPARα 1303: Activation, HSD17B4 Apr 12, 2017 Apr 12, 2017 None
2073 227: Activation, PPARα 807: Decreased, cholesterol Apr 6, 2020 May 1, 2020