Key Event Relationships (KERs)

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Showing 2901 to 2925 of 3164 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3549 2331: Activation, MR 2336: Increase, SREBF1 Jul 25, 2025 Jul 25, 2025
2862 1998: Microglia activation 188: Neuroinflammation Apr 3, 2023 Apr 3, 2023
3588 2345: Activation, MAPK 1293: Activation, FOXO Aug 16, 2025 Aug 16, 2025
3589 2345: Activation, MAPK 291: Accumulation, Triglyceride Aug 16, 2025 Aug 16, 2025
3376 1198: Activation, Macrophages 1442: Foam cell formation Oct 30, 2024 Oct 30, 2024
1606 483: Activation, LXR alpha 458: Increased, De Novo FA synthesis Jul 18, 2017 Jul 18, 2017
173 167: Activation, LXR 54: Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
174 167: Activation, LXR 66: Activation, ChREBP Nov 29, 2016 Dec 3, 2016
175 167: Activation, LXR 116: Activation, FAS Nov 29, 2016 Dec 3, 2016
176 167: Activation, LXR 258: Activation, SCD-1 Nov 29, 2016 Dec 3, 2016
177 167: Activation, LXR 264: Activation, SREBP-1c Nov 29, 2016 Dec 3, 2016
479 167: Activation, LXR 457: Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
490 167: Activation, LXR 463: Up Regulation, FAS Nov 29, 2016 Dec 3, 2016
491 167: Activation, LXR 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
510 167: Activation, LXR 468: Inhibition, PPAR alpha Nov 29, 2016 Dec 3, 2016
516 167: Activation, LXR 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) Nov 29, 2016 Dec 3, 2016
3103 167: Activation, LXR 2199: Increased, Expression of LXR activated genes Dec 7, 2023 Mar 29, 2024
1425 1314: Activation, LRH-1 116: Activation, FAS Apr 13, 2017 Apr 13, 2017 None
172 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Nov 29, 2016 Nov 29, 2016
874 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis Nov 29, 2016 Nov 29, 2016
875 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 854: Alterations, Cellular proliferation / hyperplasia Nov 29, 2016 Nov 29, 2016
876 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 856: Formation, Hepatocellular and Bile duct tumors Nov 29, 2016 Nov 29, 2016
1651 1468: TGFbeta1 activation 1469: TGFbeta pathway activation Aug 16, 2017 Aug 16, 2017
1401 1302: Activation, L-FABP 1305: Increase, cytosolic fatty acid Apr 12, 2017 Apr 12, 2017 None
1423 1302: Activation, L-FABP 228: demethylation, PPARg promoter Apr 13, 2017 Apr 13, 2017 None