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Showing 2976 to 3000 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3051	2188: Caspase activation	1825: Increase, Cell death	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1829	1575: Activation, Caspase 8 pathway	55: Cell injury/death	Jan 7, 2019	Mar 7, 2019	1 AOP 278: IKK complex inhibition leading to liver injury
1079	1038: Activation, beta-2 adrenergic receptor	1039: Increased activity, beta-2 adrenergic receptor	Nov 29, 2016	Dec 3, 2016	1 AOP 164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
3416	1038: Activation, beta-2 adrenergic receptor	2284: Intracellular cAMP	Nov 21, 2024	Nov 21, 2024	1 AOP 554: β-adrenergic receptor agonists leading to arrhythmias.
3600	2354: Activation, Apoptosis signaling	2355: Disrupted, Spermatogenesis and Sperm quality	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
1421	1309: Activation, aPKC	1301: Activation, SREBP-1	Apr 13, 2017	Apr 13, 2017	None
1661	484: Activation, AKT2	457: Activation, SREBF1	Aug 31, 2017	Aug 31, 2017	1 AOP 62: AKT2 activation leading to hepatic steatosis
1394	1299: Activation, AKT	1301: Activation, SREBP-1	Apr 12, 2017	Apr 12, 2017	None
1398	1299: Activation, AKT	1300: Activation, mTORC1	Apr 12, 2017	Apr 12, 2017	None
1400	1299: Activation, AKT	1302: Activation, L-FABP	Apr 12, 2017	Apr 12, 2017	None
18	18: Activation, AhR	17: Altered expression of AHR/ARNT pathway-dependent genes	Nov 29, 2016	Dec 3, 2016	None
19	18: Activation, AhR	80: Up Regulation, CYP1A1	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
473	18: Activation, AhR	451: Inhibition, Mitochondrial fatty acid beta-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
495	18: Activation, AhR	54: Up Regulation, CD36	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
496	18: Activation, AhR	465: Increased, FA Influx	Nov 29, 2016	Dec 3, 2016	None
499	18: Activation, AhR	216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
506	18: Activation, AhR	466: Up Regulation, LDLR (low density lipoprotein receptor)	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
509	18: Activation, AhR	450: Decrease, VLDL export capacity	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
869	18: Activation, AhR	850: Induction, CYP1A2/CYP1A5	Nov 29, 2016	May 7, 2018	2 AOPs 131: Aryl hydrocarbon receptor activation leading to uroporphyria 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
972	18: Activation, AhR	944: dimerization, AHR/ARNT	Nov 29, 2016	Mar 22, 2018	7 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
984	18: Activation, AhR	947: Increase, Early Life Stage Mortality	Nov 29, 2016	Apr 14, 2019	4 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
1656	18: Activation, AhR	462: Up Regulation, SCD-1	Aug 31, 2017	Aug 31, 2017	1 AOP 57: AhR activation leading to hepatic steatosis
1992	18: Activation, AhR	1697: Increase, DNMT expression	Oct 30, 2019	Oct 30, 2019	None
2568	18: Activation, AhR	149: Increase, Inflammation	Feb 15, 2022	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2569	18: Activation, AhR	1262: Apoptosis	Feb 15, 2022	Dec 20, 2022	1 AOP 439: Activation of the AhR leading to metastatic breast cancer

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