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Showing 2101 to 2125 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2838	1686: Energy Deposition	341: Impairment, Learning and memory	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2847	1686: Energy Deposition	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Aug 9, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2848	1686: Energy Deposition	2090: Bone Remodeling	Jan 25, 2023	Aug 9, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2849	1686: Energy Deposition	2091: Bone Loss	Jan 25, 2023	Aug 12, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
3133	1482: Depletion, mtDNA	177: Increase, Mitochondrial dysfunction	Feb 28, 2024	Feb 28, 2024	1 AOP 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
2878	130: Depletion, GSH	1115: Increase, ROS	Apr 5, 2023	Sep 14, 2023	1 AOP 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
1181	1143: Depletion, energy reserves	1140: Delayed, Sexual maturity	Nov 29, 2016	Dec 3, 2016	None
1185	1143: Depletion, energy reserves	623: Increase, predation	Nov 29, 2016	Dec 3, 2016	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
3355	2266: Demyelination, increased	2267: Delayed neuropathy, increased	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
3664	2266: Demyelination, increased	2378: Impaired axonal insulation	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1182	1140: Delayed, Sexual maturity	1141: Decreased, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
2739	2047: Delay, Ovarian maturation	2048: Increase, Body volume of female adults	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
2740	2047: Delay, Ovarian maturation	2049: Increase, sex ratio (F/M)	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
447	428: Delay, Developmental GABA shift	385: Synaptogenesis, Decreased	Nov 29, 2016	Dec 3, 2016	None
907	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	188: Neuroinflammation	Nov 29, 2016	Oct 2, 2017	1 AOP 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
910	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	896: Parkinsonian motor deficits	Nov 29, 2016	Oct 3, 2025	5 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
3077	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	637: impaired, Learning and memory	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
1383	1295: Defect of Embryogenesis	1277: Reproductive failure	Feb 15, 2017	Feb 15, 2017	1 AOP 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
2938	2147: Decreased, Viable Offspring	360: Decrease, Population growth rate	Jun 2, 2023	Sep 29, 2023	1 AOP 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
334	304: Decreased, VegfR2	305: Inhibition, VegfR2	Nov 29, 2016	Dec 3, 2016	None
768	737: Decreased, Uptake of inorganic iodide	771: Decrease, Serum thyroid hormone (T4/T3)	Nov 29, 2016	Dec 3, 2016	None
2421	737: Decreased, Uptake of inorganic iodide	277: TH synthesis, Decreased	Jul 7, 2021	Jul 7, 2021	None
1164	1116: Decreased, Triiodothyronine (T3) in tissues	1101: Altered, Amphibian metamorphosis	Nov 29, 2016	Dec 3, 2016	1 AOP 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
2238	1116: Decreased, Triiodothyronine (T3) in tissues	1023: Increased, Thyroid-stimulating hormone (TSH)	Dec 9, 2020	Dec 9, 2020	1 AOP 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
2239	1116: Decreased, Triiodothyronine (T3) in tissues	1829: Altered, TH-dependent gene expression	Dec 9, 2020	Dec 9, 2020	1 AOP 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis

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