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Showing 2901 to 2925 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

337	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	78: Reduction, Cumulative fecundity and spawning	Nov 29, 2016	Mar 20, 2017	9 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
3396	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	1467: Growth, reduction	Nov 16, 2024	Nov 16, 2024	1 AOP 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
315	285: Reduction, Vitellogenin synthesis in liver	221: Reduction, Plasma vitellogenin concentrations	Nov 29, 2016	Mar 20, 2017	7 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
1081	1040: relaxation, smooth muscle	1042: Proliferation/Clonal Expansion, smooth muscle	Nov 29, 2016	Dec 3, 2016	1 AOP 164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1564	1426: Release of G Proteins	1427: Opening of GIRK channels	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
1568	1426: Release of G Proteins	1429: Inhibition of Ca Channels	Jun 23, 2017	Jun 23, 2017	2 AOPs 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
108	87: Release, Cytokine	149: Increase, Inflammation	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
925	87: Release, Cytokine	907: Infiltration, Inflammatory cytokines	Nov 29, 2016	Dec 3, 2016	None
994	87: Release, Cytokine	901: Infiltration, Inflammatory cells	Nov 29, 2016	Nov 29, 2016	None
1963	87: Release, Cytokine	1497: Recruitment of inflammatory cells	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
2454	87: Release, Cytokine	1914: Platelet activation, Increased	Aug 4, 2021	Aug 4, 2021	1 AOP 412: Endothelial cell dysfunction leading to thromboinflammation
2455	87: Release, Cytokine	1915: Neutrophil activation, Increased	Aug 4, 2021	Aug 4, 2021	1 AOP 412: Endothelial cell dysfunction leading to thromboinflammation
1648	495: Repressed expression of steroidogenic enzymes	413: Reduction, Testosterone synthesis in Leydig cells	Aug 11, 2017	Aug 11, 2017	1 AOP 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
3615	495: Repressed expression of steroidogenic enzymes	1690: Decrease, circulating testosterone levels	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3623	495: Repressed expression of steroidogenic enzymes	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Sep 3, 2025	Sep 3, 2025	None
2436	1902: Repression of Gbx2 expression	1903: foxi1 expression, increased	Jul 14, 2021	Aug 13, 2021	1 AOP 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
433	445: Respiratory distress/arrest	351: Increased Mortality	Nov 29, 2016	Dec 20, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
592	445: Respiratory distress/arrest	590: N/A, hypoxia	Nov 29, 2016	Dec 3, 2016	1 AOP 94: Sodium channel inhibition leading to congenital malformations
378	397: Response, Keratinocytes	398: Activation, Dendritic Cells	Nov 29, 2016	Nov 29, 2016	None
380	397: Response, Keratinocytes	272: Activation/Proliferation, T-cells	Nov 29, 2016	Dec 3, 2016	None
1915	1637: Retinaldehyde dehydrogenase	1641: retinoic acid	May 22, 2019	May 22, 2019	1 AOP 297: Inhibition of retinaldehyde dehydrogenase leads to population decline
3036	2186: Activation, RyR	1350: Increased, glutamate	Sep 8, 2023	Sep 8, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
2052	1738: SARS-CoV-2 cell entry	1496: Increased proinflammatory mediators	Mar 1, 2020	Mar 1, 2020	None
2302	1738: SARS-CoV-2 cell entry	1848: TLR Activation/Dysregulation	Mar 29, 2021	Mar 29, 2021	None
2310	1738: SARS-CoV-2 cell entry	1847: SARS-CoV-2 production	Mar 30, 2021	Feb 7, 2023	2 AOPs 406: SARS-CoV-2 infection leading to hyperinflammation 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)

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