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Showing 626 to 650 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

358	385: Synaptogenesis, Decreased	386: Neuronal network function, Decreased	Nov 29, 2016	May 25, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
656	385: Synaptogenesis, Decreased	188: Neuroinflammation	Nov 29, 2016	Dec 3, 2016	None
3656	385: Synaptogenesis, Decreased	2377: neural network formation	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
443	425: Thyroidal Iodide, Decreased	281: T4 in serum, Decreased	Nov 29, 2016	Nov 29, 2016	None
872	425: Thyroidal Iodide, Decreased	277: TH synthesis, Decreased	Nov 29, 2016	Jun 4, 2018	4 AOPs 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
3720	2409: Decrease, 11β-HSD2 activity	2119: Increase, Insulin resistance	Feb 10, 2026	Feb 10, 2026	None
3731	2409: Decrease, 11β-HSD2 activity	450: Decrease, VLDL export capacity	Feb 11, 2026	Feb 11, 2026	None
3734	2409: Decrease, 11β-HSD2 activity	1306: Increase, De novo lipogenesis	Feb 11, 2026	Feb 11, 2026	None
2752	2058: Decrease, 20-hydroxyecdysone	2059: Decrease, knickkopf gene	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
1010	993: Decrease, Abdominal muscle contraction	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
2267	1834: Decrease, ACAD	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	Jan 15, 2021	Jan 15, 2021	1 AOP 318: Glucocorticoid Receptor activation leading to hepatic steatosis
2096	1771: Decrease, ATP pool	350: Increase, Mortality	Apr 30, 2020	Apr 30, 2020	2 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3)
2120	1771: Decrease, ATP pool	1775: Increase, Oocyte apoptosis	May 8, 2020	May 8, 2020	None
2121	1771: Decrease, ATP pool	1607: Increase, Necrosis	May 8, 2020	May 8, 2020	None
2179	1771: Decrease, ATP pool	1810: Decrease, ATPase activity	Nov 2, 2020	Nov 2, 2020	None
2204	1771: Decrease, ATP pool	1821: Decrease, Cell proliferation	Nov 12, 2020	Dec 7, 2020	6 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
2209	1771: Decrease, ATP pool	1366: Decrease, Oogenesis	Nov 25, 2020	Nov 25, 2020	None
2214	1771: Decrease, ATP pool	1825: Increase, Cell death	Dec 4, 2020	Dec 4, 2020	1 AOP 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
2216	1771: Decrease, ATP pool	1312: Increase, Fatty acid β-oxidation	Dec 4, 2020	Dec 4, 2020	None
2768	1771: Decrease, ATP pool	55: Cell injury/death	Sep 27, 2022	Sep 27, 2022	5 AOPs 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death
2786	1771: Decrease, ATP pool	1562: Decreased Na/K ATPase activity	Oct 19, 2022	Oct 19, 2022	1 AOP 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
3603	1771: Decrease, ATP pool	2327: Decrease, Cell growth	Aug 21, 2025	Aug 21, 2025	3 AOPs 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth
3677	1771: Decrease, ATP pool	2384: Decrease, Vascular integrity	Oct 30, 2025	Oct 30, 2025	1 AOP 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate
1937	1614: Decrease, AR activation	1615: Impaired inguinoscrotal phase	Jun 3, 2019	Jun 3, 2019	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
2124	1614: Decrease, AR activation	286: Altered, Transcription of genes by the AR	May 11, 2020	Apr 5, 2024	10 AOPs 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring

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