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Showing 101 to 125 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3022	2172: Activated Wnt/Frizzled pathway	1928: increased，Vascular endothelial dysfunction	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
1559	1421: Activated, LXR	1422: Reduced, PPARalpha	Jun 2, 2017	Jun 2, 2017	1 AOP 232: NFE2/Nrf2 repression to steatosis
1458	1355: Activated, membrane depolarization	1362: Increased, hippocampal hyperdepolarization	Apr 14, 2017	Apr 14, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1454	1351: Activated, NMDA receptor	1321: Increased, intracellular sodium (Na+)	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1452	1349: Activated, presynaptic neuron 1	1350: Increased, glutamate	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
3086	1349: Activated, presynaptic neuron 1	1018: Activation, Glutamate-gated chloride channels	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3088	1349: Activated, presynaptic neuron 1	1177: Decreased, Ionotropic GABA receptor chloride channel conductance	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
1457	1352: Activated, voltage-gated sodium channel	1355: Activated, membrane depolarization	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
2996	2169: Activation of Angiogenic cytokines	1928: increased，Vascular endothelial dysfunction	Aug 20, 2023	Aug 20, 2023	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
2995	2168: Activation of angiopoietin like protein 4	1928: increased，Vascular endothelial dysfunction	Aug 20, 2023	Aug 20, 2023	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
2705	2038: Activation, calpain	1825: Increase, Cell death	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1610	1448: activation of CEBPA	1028: Activation of specific nuclear receptors, PPAR-gamma activation	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis
1611	1448: activation of CEBPA	1449: increased adipogenesis	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis
1512	1391: Activation of Cyp2E1	1392: Increase, Oxidative Stress	May 30, 2017	Jul 1, 2021	2 AOPs 220: Cyp2E1 Activation Leading to Liver Cancer 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
1515	1391: Activation of Cyp2E1	1393: Hepatocytotoxicity	May 30, 2017	Dec 6, 2018	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
2673	2009: Activation, inflammation pathway	2010: Pulmonary inflammation	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2981	2009: Activation, inflammation pathway	1928: increased，Vascular endothelial dysfunction	Aug 19, 2023	Aug 19, 2023	2 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3006	2009: Activation, inflammation pathway	2175: Endothelial cell death	Aug 21, 2023	Aug 21, 2023	None
3007	2009: Activation, inflammation pathway	2176: Decreased endothelial cell proliferation	Aug 21, 2023	Aug 21, 2023	None
3008	2009: Activation, inflammation pathway	1472: Decrease, ATP production	Aug 21, 2023	Aug 21, 2023	None
3009	2009: Activation, inflammation pathway	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	None
2701	2036: Activation, mGLUr	389: Increased, Intracellular Calcium overload	Jul 25, 2022	Jul 25, 2022	None
2703	2036: Activation, mGLUr	2037: Activation, IP3R	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2942	2146: Activation of MEK, ERK1/2	1339: Increase, intracellular calcium	Jun 20, 2023	Apr 11, 2024	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
2994	2167: Activation of MMP-2 MMP-9	1928: increased，Vascular endothelial dysfunction	Aug 20, 2023	Aug 20, 2023	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects

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