Key Event Relationships (KERs)

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Showing 1726 to 1750 of 3182 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3136 177: Increase, Mitochondrial dysfunction 1585: Proteasomal dysfunction Feb 29, 2024 Feb 29, 2024
3141 177: Increase, Mitochondrial dysfunction 1115: Increase, ROS Mar 6, 2024 Apr 11, 2024
3146 177: Increase, Mitochondrial dysfunction 1262: Apoptosis Mar 13, 2024 Mar 13, 2024
3149 177: Increase, Mitochondrial dysfunction 1263: Necrosis Mar 13, 2024 Mar 13, 2024
3150 177: Increase, Mitochondrial dysfunction 1762: cell injury Mar 13, 2024 Mar 13, 2024
3152 177: Increase, Mitochondrial dysfunction 1817: Apoptotic cell death Mar 13, 2024 Mar 13, 2024
3153 177: Increase, Mitochondrial dysfunction 1815: Increase, ER stress Mar 13, 2024 Mar 13, 2024
3155 177: Increase, Mitochondrial dysfunction 833: Occurrence, Cytoplasmic vacuolization (hepatocyte) Mar 13, 2024 Mar 13, 2024
3156 177: Increase, Mitochondrial dysfunction 835: Occurrence, Ballooning degeneration (hepatocyte) Mar 13, 2024 Mar 13, 2024
3157 177: Increase, Mitochondrial dysfunction 837: Occurrence, Cytoplasmic vacuolization (kupffer cell) Mar 13, 2024 Mar 13, 2024
3158 177: Increase, Mitochondrial dysfunction 836: Occurrence, Cytoplasmic vacuolization (Bile duct cell) Mar 13, 2024 Mar 13, 2024
3161 177: Increase, Mitochondrial dysfunction 2144: Impaired insulin signaling Mar 13, 2024 Mar 13, 2024
3164 177: Increase, Mitochondrial dysfunction 1917: Altered expression of NRF2 pathway-dependent genes Mar 14, 2024 Mar 14, 2024
3165 177: Increase, Mitochondrial dysfunction 202: Inhibition, Nuclear factor kappa B (NF-kB) Mar 14, 2024 Mar 14, 2024
3767 177: Increase, Mitochondrial dysfunction 188: Neuroinflammation Apr 2, 2026 Apr 2, 2026
2797 2072: Increase, Mitochondrial swelling 55: Cell injury/death Nov 1, 2022 Nov 1, 2022
198 350: Increase, Mortality 328: Decrease, Fecundity Nov 29, 2016 Dec 3, 2016 None
199 350: Increase, Mortality 361: Decline, Population Nov 29, 2016 Dec 3, 2016 None
1004 350: Increase, Mortality 765: Decreased, population 1 Nov 29, 2016 Dec 3, 2016 None
1013 350: Increase, Mortality 997: Decreased, Population size Nov 29, 2016 Dec 3, 2016 None
2463 350: Increase, Mortality 360: Decrease, Population growth rate Aug 5, 2021 Aug 5, 2021 None
991 962: Increase, Mucin production 943: Hypersecretion, Mucus Nov 29, 2016 Nov 29, 2016 None
1315 962: Increase, Mucin production 1251: Chronic, Mucus hypersecretion Nov 29, 2016 Aug 30, 2021 None
2859 962: Increase, Mucin production 1250: Decreased lung function Mar 15, 2023 Mar 16, 2023
1486 1374: Increase, mucosal blood flow 1380: Activate, mucosal defense Apr 17, 2017 Apr 17, 2017