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Showing 1726 to 1750 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1516	1392: Increase, Oxidative Stress	1395: Liver Cancer	May 30, 2017	Jun 19, 2021	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
1685	1392: Increase, Oxidative Stress	1488: Glutamate dyshomeostasis	Nov 9, 2017	Feb 6, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1690	1392: Increase, Oxidative Stress	55: Cell injury/death	Nov 9, 2017	Feb 7, 2020	4 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress
2008	1392: Increase, Oxidative Stress	1645: Wnt ligand stimulation	Dec 3, 2019	Dec 3, 2019	None
2289	1392: Increase, Oxidative Stress	1845: Coagulation	Mar 25, 2021	Mar 25, 2021	None
2449	1392: Increase, Oxidative Stress	1906: CFTR Function, Decreased	Jul 30, 2021	Sep 28, 2021	1 AOP 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
2450	1392: Increase, Oxidative Stress	1911: FOXJ1 Protein, Decreased	Aug 2, 2021	Sep 28, 2021	1 AOP 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
2451	1392: Increase, Oxidative Stress	1908: CBF, Decreased	Aug 2, 2021	Mar 24, 2023	1 AOP 411: Oxidative stress Leading to Decreased Lung Function
2505	1392: Increase, Oxidative Stress	1943: p-Tau	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2674	1392: Increase, Oxidative Stress	2010: Pulmonary inflammation	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2714	1392: Increase, Oxidative Stress	1547: Mitochondrial Injury	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2716	1392: Increase, Oxidative Stress	1825: Increase, Cell death	Jul 25, 2022	Aug 23, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2771	1392: Increase, Oxidative Stress	2066: Altered Signaling	Sep 28, 2022	Feb 13, 2024	None
2772	1392: Increase, Oxidative Stress	1493: Increased pro-inflammatory mediators	Sep 28, 2022	Aug 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
2774	1392: Increase, Oxidative Stress	2067: Altered, Nitric Oxide Levels	Sep 28, 2022	Nov 26, 2024	1 AOP 470: Deposition of energy leads to abnormal vascular remodeling
2776	1392: Increase, Oxidative Stress	2068: Increase, Endothelial Dysfunction	Sep 28, 2022	Aug 27, 2024	2 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 462: Activation of reactive oxygen species leading the atherosclerosis
2810	1392: Increase, Oxidative Stress	1634: Increase, Oxidative DNA damage	Dec 16, 2022	Mar 8, 2024	2 AOPs 478: Deposition of energy leading to occurrence of cataracts 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
2811	1392: Increase, Oxidative Stress	1635: Increase, DNA strand breaks	Dec 16, 2022	Jul 29, 2024	3 AOPs 478: Deposition of energy leading to occurrence of cataracts 483: Deposition of Energy Leading to Learning and Memory Impairment 470: Deposition of energy leads to abnormal vascular remodeling
2812	1392: Increase, Oxidative Stress	2081: Modified Proteins	Dec 16, 2022	Mar 30, 2023	1 AOP 478: Deposition of energy leading to occurrence of cataracts
2818	1392: Increase, Oxidative Stress	2083: Cataracts	Dec 18, 2022	Mar 11, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
2827	1392: Increase, Oxidative Stress	1816: Mitochondrial dysfunction EMPTY	Jan 9, 2023	Jan 9, 2023	None
2833	1392: Increase, Oxidative Stress	1492: Tissue resident cell activation	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2846	1392: Increase, Oxidative Stress	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Aug 12, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2975	1392: Increase, Oxidative Stress	149: Increase, Inflammation	Jul 31, 2023	Oct 19, 2023	1 AOP 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
3047	1392: Increase, Oxidative Stress	1605: Accumulation, misfolded proteins	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits

Key Event Relationships (KERs)

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