AOP-Wiki

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Showing 1776 to 1800 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3264	1392: Increase, Oxidative Stress	1097: Occurrence, renal proximal tubular necrosis	Jul 3, 2024	Jul 3, 2024	4 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3267	1392: Increase, Oxidative Stress	1194: Increase, DNA Damage	Jul 4, 2024	Jul 4, 2024	2 AOPs 200: Estrogen receptor activation leading to breast cancer 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
3270	1392: Increase, Oxidative Stress	1365: Increase, Apoptosis	Jul 4, 2024	Jul 4, 2024	2 AOPs 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
3272	1392: Increase, Oxidative Stress	2144: Impaired insulin signaling	Jul 4, 2024	Jul 4, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
3274	1392: Increase, Oxidative Stress	277: TH synthesis, Decreased	Jul 4, 2024	Jul 4, 2024	2 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
3277	1392: Increase, Oxidative Stress	2009: Activation, inflammation pathway	Jul 4, 2024	Jul 4, 2024	2 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3279	1392: Increase, Oxidative Stress	2166: Abnormal expression of NO	Jul 4, 2024	Jul 4, 2024	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
3280	1392: Increase, Oxidative Stress	2170: Activated ANG/Tie2 pathway	Jul 4, 2024	Jul 4, 2024	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3281	1392: Increase, Oxidative Stress	2164: Activation, Dll4-Notch pathway	Jul 4, 2024	Jul 4, 2024	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3282	1392: Increase, Oxidative Stress	2171: Activated BMP/TGF-beta pathway	Jul 4, 2024	Jul 4, 2024	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3283	1392: Increase, Oxidative Stress	2172: Activated Wnt/Frizzled pathway	Jul 4, 2024	Jul 4, 2024	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3284	1392: Increase, Oxidative Stress	932: Uncoupling, eNOS	Jul 4, 2024	Jul 4, 2024	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3285	1392: Increase, Oxidative Stress	2173: Activated AKT/ERK/PI3K pathway	Jul 4, 2024	Jul 4, 2024	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3286	1392: Increase, Oxidative Stress	2174: Inhibition VEGF/VEGFR pathway	Jul 4, 2024	Jul 4, 2024	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3293	1392: Increase, Oxidative Stress	2240: The NO synthase pathway activation	Jul 9, 2024	Jul 9, 2024	1 AOP 538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
3294	1392: Increase, Oxidative Stress	2241: Ferroptosis related pathways activation	Jul 9, 2024	Jul 9, 2024	1 AOP 538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
3310	1392: Increase, Oxidative Stress	1511: Lipid Peroxidation	Jul 23, 2024	Jul 23, 2024	1 AOP 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
3311	1392: Increase, Oxidative Stress	1512: Unfolded Protein Response	Jul 23, 2024	Jul 23, 2024	1 AOP 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
3312	1392: Increase, Oxidative Stress	352: N/A, Neurodegeneration	Jul 23, 2024	Jul 23, 2024	2 AOPs 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Neuron defect induced early behavioral change
3314	1392: Increase, Oxidative Stress	386: Neuronal network function, Decreased	Jul 23, 2024	Jul 23, 2024	1 AOP 501: Excessive iron accumulation leading to neurological disorders
3316	1392: Increase, Oxidative Stress	2244: Altered Stress Response Signaling	Jul 24, 2024	Aug 26, 2024	2 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment
3319	1392: Increase, Oxidative Stress	2245: Altered cell differentiation signaling	Jul 24, 2024	Aug 23, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
3322	1392: Increase, Oxidative Stress	618: Decreased, Neuronal network function in adult brain	Jul 24, 2024	Jul 24, 2024	1 AOP 471: Neuron defect induced early behavioral change
3324	1392: Increase, Oxidative Stress	131: Down Regulation, Gulcose-6-phosphate dehydrogenase	Jul 24, 2024	Jul 24, 2024	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
3325	1392: Increase, Oxidative Stress	250: Damaging, Red blood cells; hemolysis	Jul 24, 2024	Jul 24, 2024	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity

Key Event Relationships (KERs)

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