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All KERs

Showing 2101 to 2125 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1048	1012: Increased, Inhibitory postsynaptic potential	1013: Inhibition, Motor neuron activity	Nov 29, 2016	Dec 3, 2016	None
1054	1012: Increased, Inhibitory postsynaptic potential	1014: Induction, Somatic muscle paralysis	Nov 29, 2016	Dec 3, 2016	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 471: Neuron defect induced early behavioral change
1058	1012: Increased, Inhibitory postsynaptic potential	1019: Induction, pharyngeal muscle paralysis	Nov 29, 2016	Dec 3, 2016	1 AOP 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
547	493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts	376: Increased, Induced Mutations in Critical Genes	Nov 29, 2016	Nov 29, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
362	389: Increased, Intracellular Calcium overload	177: Increase, Mitochondrial dysfunction	Nov 29, 2016	Nov 29, 2016	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
892	389: Increased, Intracellular Calcium overload	618: Decreased, Neuronal network function in adult brain	Nov 29, 2016	Dec 3, 2016	None
1860	389: Increased, Intracellular Calcium overload	613: Occurrence, Epileptic seizure	Feb 13, 2019	Feb 13, 2019	None
1862	389: Increased, Intracellular Calcium overload	55: Cell injury/death	Feb 19, 2019	Sep 3, 2023	1 AOP 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
2140	389: Increased, Intracellular Calcium overload	1788: Status epilepticus	May 21, 2020	May 21, 2020	None
2704	389: Increased, Intracellular Calcium overload	2038: Activation, calpain	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2709	389: Increased, Intracellular Calcium overload	1477: OXPHOS, decreased	Jul 25, 2022	Jul 25, 2022	None
2710	389: Increased, Intracellular Calcium overload	2017: Endoplasmic reticulum stress	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3042	389: Increased, Intracellular Calcium overload	1816: Mitochondrial dysfunction EMPTY	Sep 14, 2023	Sep 14, 2023	None
3091	389: Increased, Intracellular Calcium overload	2078: Loss of drebrin	Oct 18, 2023	Apr 4, 2025	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
3248	389: Increased, Intracellular Calcium overload	1392: Increase, Oxidative Stress	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
3256	389: Increased, Intracellular Calcium overload	2151: Disruption, neurotransmitter release	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
3426	389: Increased, Intracellular Calcium overload	1532: Decrease, Cardiac contractility	Nov 21, 2024	Nov 21, 2024	2 AOPs 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
1465	1322: Increased, intracellular chloride (Cl-)	1356: Inactive, membrane depolarization	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
1525	1398: Increased, intracellular serotonin	1399: Increased, packaged serotonin	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1455	1321: Increased, intracellular sodium (Na+)	1352: Activated, voltage-gated sodium channel	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
3424	1321: Increased, intracellular sodium (Na+)	2287: Impaired Sodium-Calcium Exchange	Nov 21, 2024	Nov 21, 2024	1 AOP 556: Decreased Na/K ATPase activity leading to heart failure
2576	1196: Increased, Invasion	1193: N/A, Breast Cancer	Feb 15, 2022	Feb 15, 2022	None
3138	1196: Increased, Invasion	1982: Metastasis, Breast Cancer	Mar 5, 2024	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2462	759: Increased, Kidney Failure	350: Increase, Mortality	Aug 5, 2021	Aug 5, 2021	None
2466	759: Increased, Kidney Failure	351: Increased Mortality	Aug 11, 2021	Aug 11, 2021	1 AOP 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure

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