Prototypical Stressors

Showing 301 to 325 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

604	Dinoseb	Dinoseb, CAS-RN: 88-85-7, DTXSID3020207	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
214	DIOFENOLAN	Diofenolan, CAS-RN: 63837-33-2, DTXSID2041884	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
349	dioxin		None
20	Dioxin and dioxin-like compounds	2,3,7,8-Tetrachlorodibenzo-p-dioxin, CAS-RN: 1746-01-6, DTXSID2021315 Acetamide, CAS-RN: 60-35-5, DTXSID7020005	None
199	diphacinone	Diphacinone, CAS-RN: 82-66-6, DTXSID4032378	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
412	Discodermolide		None
704	Disopyramide	Disopyramide, CAS-RN: 3737-09-5, DTXSID1045536	None
310	Disulfiram	Tetraethylthiuram disulfide, CAS-RN: 97-77-8, DTXSID1021322	2 AOPs 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
461	Disulphiram		297: Inhibition of retinaldehyde dehydrogenase leads to population decline
367	Diuron	Diuron, CAS-RN: 330-54-1, DTXSID0020446	2 AOPs 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
532	Dodecylbenzene sulfonate		154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
801	Dofetilide		555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
21	Domoic acid	L-Domoic acid, CAS-RN: 14277-97-5, DTXSID20274180	None
813	Donepezil		559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
285	Doxorubicin	Doxorubicin, CAS-RN: 23214-92-8, DTXSID8021480	None
627	Dummy Stressor		None
621	DX600		319: Binding to ACE2 leading to lung fibrosis
69	Dysidenin		54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
803	E-4031		2 AOPs 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure
247	Ecdysone		4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
219	Econazole		None
302	EGFR ligand		None
843	Elesclomol		590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
83	Emamectin benzoate	Emamectin benzoate, CAS-RN: 155569-91-8, DTXSID0034566	2 AOPs 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
605	Emodin	Emodin, CAS-RN: 518-82-1, DTXSID5025231	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation