Prototypical Stressors

Showing 651 to 675 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

326	Cidofovir	Cidofovir, CAS-RN: 113852-37-2, DTXSID3043734	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
864	Chrysene	Chrysene, CAS-RN: 218-01-9, DTXSID0022432	3 AOPs 644: Bulky DNA adducts leading to chromosomal aberrations and mutations 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
713	Chromium	Chromium, CAS-RN: 7440-47-3, DTXSID3031022	None
243	Chromafenozide	Chromafenozide, CAS-RN: 143807-66-3, DTXSID4057976	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
787	Cholinergic drugs		551: Increased Muscarinic M2 Receptor leading to Arrhythmia
680	Cholesterol	Cholesterol, CAS-RN: 57-88-5, DTXSID3022401	None
356	Chlorzoxazone	Chlorzoxazone, CAS-RN: 95-25-0, DTXSID9022813	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
766	Chlorpyrifos oxon	Chlorpyrifos oxon, CAS-RN: 5598-15-2, DTXSID1038666	490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
280	Chlorpyrifos	Chlorpyrifos, CAS-RN: 2921-88-2, DTXSID4020458	3 AOPs 202: Inhibitor binding to topoisomerase II leading to infant leukaemia 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
117	Chlorpromazine	Chlorpromazine, CAS-RN: 50-53-3, DTXSID0022808	None
856	Chlorotoluron	Chlorotoluron, CAS-RN: 15545-48-9, DTXSID8052853	567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
389	Chloroquine bis(phosphate)	Chloroquine bis(phosphate), CAS-RN: 50-63-5, DTXSID7044681	144: Endocytic lysosomal uptake leading to liver fibrosis
198	chlorophacinone	Chlorophacinone, CAS-RN: 3691-35-8, DTXSID2032348	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
142	Chloroform	Chloroform, CAS-RN: 67-66-3, DTXSID1020306	None
473	CHIR99021		None
478	CHIR98014		None
480	CHIR-99021	CHIR-99021, CAS-RN: 252917-06-9, DTXSID90179931	None
481	CHIR-98014		None
355	Chemical:584015 (1-~13~C)Aniline		260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
630	Chemical:33664 17-Methyltestosterone		376: Androgen receptor agonism leading to male-biased sex ratio
439	Chemical:20384 Dexamethasone, minocycline, innamicaldehyde		None
240	Chemical		205: AOP from chemical insult to cell death
507	Cetrorelix	Cetrorelix, CAS-RN: 120287-85-6, DTXSID7040996	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
628	cell free mitochondrial DNA (mtDNA)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
86	Celecoxib	Celecoxib, CAS-RN: 169590-42-5, DTXSID0022777	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality