Prototypical Stressors

Showing 176 to 200 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

822	Carbofuran		559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
740	Carbon black	Carbon black, CAS-RN: 1333-86-4, DTXSID7051216	451: Interaction with lung resident cell membrane components leads to lung cancer
318	Carbon nanotubes		3 AOPs 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis 409: Frustrated phagocytosis leads to malignant mesothelioma
339	Carbon nanotubes, Multi-walled carbon nanotubes, Single-walled carbon nanotubes, carbon fibres		None
338	Carbon nanotubes, Multi-walled carbon nanotubes, single-walled carbon nanotubes, carbon nanofibres		2 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 409: Frustrated phagocytosis leads to malignant mesothelioma
13	Carbon tetrachloride	Carbon tetrachloride, CAS-RN: 56-23-5, DTXSID8020250	38: Protein Alkylation leading to Liver Fibrosis
602	Carbonyl cyanide m-chlorophenyl hydrazone		263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
601	Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone		263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
194	Carprofen	Carprofen, CAS-RN: 53716-49-7, DTXSID1045871	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
809	Catecholamines		558: Phosphodiesterase inhibition leading to heart failure
622	cationic polyamidoamine dendrimer (nanoparticle)		319: Binding to ACE2 leading to lung fibrosis
86	Celecoxib	Celecoxib, CAS-RN: 169590-42-5, DTXSID0022777	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
628	cell free mitochondrial DNA (mtDNA)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
507	Cetrorelix	Cetrorelix, CAS-RN: 120287-85-6, DTXSID7040996	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
240	Chemical		205: AOP from chemical insult to cell death
439	Chemical:20384 Dexamethasone, minocycline, innamicaldehyde		None
630	Chemical:33664 17-Methyltestosterone		376: Androgen receptor agonism leading to male-biased sex ratio
355	Chemical:584015 (1-~13~C)Aniline		260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
481	CHIR-98014		None
480	CHIR-99021	CHIR-99021, CAS-RN: 252917-06-9, DTXSID90179931	None
478	CHIR98014		None
473	CHIR99021		None
142	Chloroform	Chloroform, CAS-RN: 67-66-3, DTXSID1020306	None
198	chlorophacinone	Chlorophacinone, CAS-RN: 3691-35-8, DTXSID2032348	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
389	Chloroquine bis(phosphate)	Chloroquine bis(phosphate), CAS-RN: 50-63-5, DTXSID7044681	144: Endocytic lysosomal uptake leading to liver fibrosis